D
David Lawrence
Researcher at Novartis
Publications - 67
Citations - 2433
David Lawrence is an academic researcher from Novartis. The author has contributed to research in topics: Indacaterol & COPD. The author has an hindex of 21, co-authored 66 publications receiving 2104 citations. Previous affiliations of David Lawrence include University College London Hospitals NHS Foundation Trust & University College Hospital.
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Journal ArticleDOI
Imatinib Mesylate as Add-On Therapy for Pulmonary Arterial Hypertension: Results of the Randomized IMPRES Study
Marius M. Hoeper,Robyn J. Barst,Robert C. Bourge,Jeremy Feldman,Adaani E. Frost,Nazzareno Galiè,Miguel Ángel Gómez-Sánchez,Friedrich Grimminger,Ekkehard Grünig,Paul M. Hassoun,Nicholas W. Morrell,Andrew J. Peacock,Toru Satoh,Gérald Simonneau,Victor F. Tapson,Fernando Torres,David Lawrence,Deborah A. Quinn,Hossein Ardeschir Ghofrani +18 more
TL;DR: Imatinib in Pulmonary Arterial Hypertension, a Randomized, Efficacy Study (IMPRES), a randomized, double-blind, placebo-controlled 24-week trial, evaluated imatinib as mentioned in this paper in patients with pulmonary vascular resistance ≥800 dyne·s·cm−5 symptomatic on ≥2 PAH therapies.
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Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study
Marc Decramer,Kenneth R. Chapman,Ronald Dahl,Peter Frith,Gilles Devouassoux,Carlos Cezar Fritscher,Ray Cameron,Muhammad Shoaib,David Lawrence,David Young,Danny McBryan +10 more
TL;DR: Indacaterol and tiotropium provided clinically relevant improvements in lung function with comparable safety profiles and the present data offer evidence consistent with current guidelines.
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Lung cancer diagnosis and staging with endobronchial ultrasound-guided transbronchial needle aspiration compared with conventional approaches: an open-label, pragmatic, randomised controlled trial
Neal Navani,Neal Navani,Neal Navani,Matthew Nankivell,David Lawrence,Sara Lock,H K Makker,David R Baldwin,Richard Stephens,Mahesh K. B. Parmar,Stephen G. Spiro,Stephen Morris,Sam M. Janes,Sam M. Janes +13 more
TL;DR: Transbronchial needle aspiration guided by endobronchia ultrasound should be considered as the initial investigation for patients with suspected lung cancer, because it reduces the time to treatment decision compared with conventional diagnosis and staging techniques.
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Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: a randomised controlled clinical trial
Luciano Candilio,Abdul Malik,Cono Ariti,Matthew Barnard,Carmelo Di Salvo,David Lawrence,Martin Hayward,John Yap,Neil Roberts,Amir M. Sheikh,Shyam Kolvekar,Derek J. Hausenloy,Derek M. Yellon +12 more
TL;DR: Remote ischaemic preconditioning (RIPC), using brief cycles of limb ischaemia/reperfusion, is a non-invasive, low-cost intervention that may reduce perioperative myocardial injury (PMI) in patients undergoing cardiac surgery and may also improve short-term clinical outcomes.
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Effect of indacaterol on exercise endurance and lung hyperinflation in COPD
Denis E. O'Donnell,Richard Casaburi,Walter Vincken,Luis Puente-Maestu,James Swales,David Lawrence,Benjamin Kramer +6 more
TL;DR: In conclusion, indacaterol treatment improved the ability of patients with COPD to exercise, and improvements observed in resting and end-exercise IC indicate reductions in lung hyperinflation after 3 weeks treatment.