David Lee Nelson

TL;DR: The cloned human 5-HT2B receptor has high affinity for [3H]5-HT (Kd = 10.6 +/- 1.5 nM), and the pharmacological findings reinforce the desirability of having the human forms of receptors when considering drug actions.

TL;DR: The identification of multiple subtypes of serotonin receptors expressed in cultured embryonic sensory neurons suggests that DRG neuronal cultures may be an excellent model to examine the direct effects of serotonin on the activity of these sensory neurons.

TL;DR: The TAAR1 receptor exhibits a pharmacologic profile uniquely different from those of classic monoaminergic receptors, consistent with the structural information that places them in a distinct family of receptors, and suggests the potential for development of TAAR-selective agonists and antagonists to study their physiologic roles.

TL;DR: The development and evaluation of the capacity of nanoemulsions to improve the activity of the novel schistosomicidal drug-2-(butylamino)-1-phenyl-1-ethanethiosulfuric acid (BphEA) and release studies revealed a good stability of NANOSTE containing BphEA in a biological medium indicate that cationic nanoemulesions can represent an interesting delivery system for the pharmaceutical formulation of Bph EA.