Showing papers in "European Journal of Pharmacology in 1986"

TL;DR: The effects of MDA or MDMA administration in the rat brain are reminiscent of those elicited by p-chloroamphetamine, a presumed serotonergic neurotoxin, suggesting that both drugs influence dopamine turnover.

TL;DR: Diabetes leads to an impairment of the endothelium-dependent relaxation of aorta, and the relaxation induced by sodium nitroprusside in diabetic preparations was comparable to the control.

TL;DR: Administered independently, the selective D-1 and D-2 agonists SKF 38393 and LY 171555 elicited dose dependent increases in complex motor behaviors such as locomotion or grooming and AMPT pretreatment blocked the effects of the agonists administered independently, but all classes of behavior could be induced when they were administered in combination.

TL;DR: During microiontophoretic application, (-)-propranolol rapidly and reversibly blocked the suppressant effects of the 5-HT1A-selective agonists ipsapirone and 8-hydroxy-2-(di-n-propylamino)tetralin, suggesting that the endogenous neurotransmitter may have actions on dorsal raphe neurons in addition to those mediated by 5- HT1A receptors.

TL;DR: It is concluded that, with certain limitations, the burying-grooming test described offers a simple tool for identifying novel compounds as potential major or minor tranquilizers.

TL;DR: Correlation of these biochemical findings with human subjective reports indicates that serotonin release may play a more important role in the mechanism of action than does dopamine release.

TL;DR: In rat cerebral cortex, the rank order of potency of tachykinins and related analogues in displacing 125I-BHE was distinct from that of peripheral SP-E sites, with neurokinin B being the most potent displacer, and SPOMe was over 1,000 times more active than I-BHSPOMe.

TL;DR: Data indicate that SCH 23390 also binds with high affinity to 5-HT2 receptors in rat brain, and is equipotent to the two 5- HT2 antagonists cinanserin and methysergide.

TL;DR: The present study supports the notion that central serotonergic systems may be involved in the therapeutic effects of anxiolytic drugs by concluding that buspirone potently and directly inhibits the firing of Serotonergic dorsal raphe neurons in the rat.

TL;DR: The results support the existence of two glycine receptor subtypes: strychnine-sensitive and stry Schnine-insensitive, which were found to be of high affinity, stereoselective and displaced by structurally related amino acids.

TL;DR: The kinetics of (-)-[3H]rolipram binding to the particulate fraction revealed a complex association and dissociation behaviour, which may represent a rolipram-sensitive phosphodiesterase isoenzyme also common to some peripheral organs, while the high affinity binding site(s) may be related to PDE isoenzymes more confined to the central nervous system.

TL;DR: It can be concluded that hippocampal cholinergic terminals are endowed with inhibitory 5-HT receptors which appear to belong to the 5- HT1B subtype.

TL;DR: MPTP produced variable effects on neostriatal dopamine levels in different strains of mice as well as in Swiss-Webster mice obtained from different sources.

TL;DR: CGP 20712 A (1]-2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino]-3- [4-(1-methyl-4trifluoromethyl-2-imidazolyl) phenoxy]-2propanol methanesulfonate), a specific beta 1-adrenoceptor antagonist, was tested for resolution of beta 1 and beta 2-ADROceptors in an in vitro [3H]dihydroalprenolol ([3

TL;DR: Results suggest that 8-OH-DPAT induced hyperphagia is mediated via a agonist action on somatodendritic 5-HT autoreceptors, and decreased 5-HIAA and 5- HIAA/5-HT ratio in several brain regions.

TL;DR: Observations suggest that both the D-1 and D-2 dopamine receptor systems participate in the regulation of rotational behaviors in striatally lesioned rats with normosensitive DA receptors.

TL;DR: The amphetamine analogue, methylenedioxymethamphetamine (MDMA) has received considerable attention recently as a novel and increasingly popular psychoactive agent when administered acutely to rats in high doses, and caused a selective and dramatic decrease in brain concentrations of serotonin and its metabolite, 5-hydroxyindoleacetic acid.

TL;DR: It is concluded that ATP and noradrenaline are excitatory cotransmitters from sympathetic perivascular nerves innervating the rabbit central ear artery.

TL;DR: It is concluded that the property of B-HT 920 to stimulate the 'denervated' supersensitive (reserpine, 6-OH-dopamine, MPTP) but not the normosensitive postsynaptic dopamine receptor in the striatum may represent a novel principle for a specific approach to dopamine substitution treatment of Parkinson's disease.

TL;DR: 8-OH-DPAT appears to stimulate eating by acting on 5-HT-containing neurons, compatible with the hypothesis that a decrease in central 5- HT function disinhibits feeding.

TL;DR: Naloxonazine antagonized morphine analgesia for greater than 24 h without altering lethality and was associated with a wash-resistant inhibition of binding lasting 24 h which was relatively selective for mu 1 sites, indicating relatively selective mu 1 affinity label in binding studies.

TL;DR: The results show that the d- and l-isomers of fenfluramine at relatively low doses have a specific action on brain 5-HT and catecholamines, respectively.

TL;DR: NK-A receptors for neurokinins (which are present in the tracheo-bronchial tree) are also to be found in pulmonary vessels and mediate contraction of arterial vascular smooth muscle, an interesting property of Neurokinins.

TL;DR: It was found that (-)-pindolol elicited a clearcut, selective, dose-dependent and stereospecific reduction of brain 5-HT synthesis rate, and the possibility is considered that, in addition to its beta-adrenergic properties, (--pINDolol is a mixed agonist-antagonist at central 5- HT receptors.

TL;DR: An intracerebral dialysis method was used in the halothane-anaesthetized rat to further clarify the site which mediates the amphetamine-induced decrease of the striatal dopamine (DA) metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA).