D
David Loebenberg
Researcher at Schering-Plough
Publications - 119
Citations - 6469
David Loebenberg is an academic researcher from Schering-Plough. The author has contributed to research in topics: Posaconazole & Candida albicans. The author has an hindex of 35, co-authored 119 publications receiving 6213 citations. Previous affiliations of David Loebenberg include Merck & Co..
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Nonfilamentous C. albicans mutants are avirulent.
Hsiu-Jung Lo,Julia R. Köhler,Julia R. Köhler,Beth DiDomenico,David Loebenberg,Anthony Cacciapuoti,Gerald R. Fink +6 more
TL;DR: This Candida cph1/cph1 efg1/efg1 double mutant, locked in the yeast form, is avirulent in a mouse model.
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In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts.
F J Sabatelli,Reena Patel,Paul A. Mann,Cara Mendrick,Christine Norris,Roberta S. Hare,David Loebenberg,Todd A. Black,Paul M. McNicholas +8 more
TL;DR: Posaconazole exhibited potent antifungal activity against a wide variety of clinically important fungal pathogens and was frequently more active than other azoles and amphotericin B.
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Three-Dimensional Models of Wild-Type and Mutated Forms of Cytochrome P450 14α-Sterol Demethylases from Aspergillus fumigatus and Candida albicans Provide Insights into Posaconazole Binding
Li Xiao,Vincent S. Madison,Andrew S. Chau,David Loebenberg,Robert Palermo,Paul M. McNicholas +5 more
TL;DR: In this paper, homology models of the CYP51 enzymes from Aspergillus fumigatus and Candida albicans were constructed based on the X-ray crystal structure of the enzyme from Mycobacterium tuberculosis.
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Mutations in Aspergillus fumigatus Resulting in Reduced Susceptibility to Posaconazole Appear To Be Restricted to a Single Amino Acid in the Cytochrome P450 14α-Demethylase
Paul A. Mann,Raulo Parmegiani,Shui-Qing Wei,Cara Mendrick,Xin Li,David Loebenberg,Beth DiDomenico,Roberta S. Hare,Scott S. Walker,Paul M. McNicholas +9 more
TL;DR: The transformants exhibited reductions in susceptibility to POS comparable to those exhibited by the original mutants, confirming that point mutations in the cyp51A gene in A. fumigatus can confer reduced susceptibility to Posaconazole.
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Application of Real-Time Quantitative PCR to Molecular Analysis of Candida albicans Strains Exhibiting Reduced Susceptibility to Azoles
TL;DR: Despite both the increases in pump expression and the ERG11 mutations, only one of the patient isolates exhibited a large decrease in posaconazole susceptibility.