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David M. Graham
Researcher at University of North Carolina at Chapel Hill
Publications - 18
Citations - 826
David M. Graham is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cellular polarity & Wnt signaling pathway. The author has an hindex of 13, co-authored 17 publications receiving 627 citations. Previous affiliations of David M. Graham include Woods Hole Oceanographic Institution & Marine Biological Laboratory.
Papers
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Journal ArticleDOI
Extracellular Electrical Fields Direct Wound Healing and Regeneration
Mark A. Messerli,David M. Graham +1 more
TL;DR: The generation of endogenous EFs, the results of their alteration, and the mechanisms by which cells may sense these weak fields are reviewed to enable current and future therapeutic applications to be optimized.
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Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12)
TL;DR: It is confirmed that ZIP12 is a Zn2+ uptake transporter with a conserved pattern of high expression in the mouse and Xenopus nervous system and provides tangible links between Zn 2+, neurulation, and neuronal differentiation.
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Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction
David M. Graham,Tomas Andersen,Lisa Sharek,Gunes Uzer,Gunes Uzer,Katheryn E. Rothenberg,Brenton D. Hoffman,Janet Rubin,Martial Balland,James E. Bear,Keith Burridge +10 more
TL;DR: It is found that polarity establishment and cell migration in one dimension (1D) and two dimensions (2D) occur without the nucleus, and the nucleus is dispensable for polarization and migration in 1D and 2D but critical for proper cell mechanical responses.
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Mechanotransduction and nuclear function
David M. Graham,Keith Burridge +1 more
TL;DR: A brief review of some of the key proteins that transmit mechanical signals across the nuclear envelope and how force is transmitted via the cytoskeleton to the nucleus and then across thenuclear envelope to the nuclear lamina and chromatin is focused on.
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Mechanotransduction: from the cell surface to the nucleus via RhoA
TL;DR: This review considers how forces exerted on cell adhesion molecules at the cell surface regulate the RhoA signalling pathway by controlling the activities of guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs).