D
David Main
Researcher at Georgetown University
Publications - 26
Citations - 4356
David Main is an academic researcher from Georgetown University. The author has contributed to research in topics: Smoking cessation & Genetic counseling. The author has an hindex of 26, co-authored 26 publications receiving 4291 citations. Previous affiliations of David Main include Georgetown University Medical Center & University of Toronto.
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Journal ArticleDOI
BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes.
Caryn Lerman,Steven A. Narod,Kevin A. Schulman,Chanita Hughes,Andres Gomez-Caminero,George E. Bonney,Karen Gold,Bruce J. Trock,David Main,Jane F. Lynch,Cecil Fulmore,Carrie Snyder,Stephen J. Lemon,Theresa Conway,Patricia N. Tonin,Gilbert M. Lenoir,Henry T. Lynch +16 more
TL;DR: Only a subset of HBOC family members are likely to request BRCA1 testing when available and rates of test use may be higher in persons of a higher socioeconomic status and those with more relatives affected with breast cancer.
Journal ArticleDOI
Evidence suggesting the role of specific genetic factors in cigarette smoking.
Caryn Lerman,Neil E. Caporaso,Janet Audrain,David Main,Elise D. Bowman,Benjamin Lockshin,Neal R. Boyd,Peter G. Shields +7 more
TL;DR: Preliminary evidence that the SLC6A3 gene may influence smoking initiation and nicotine dependence is provided, indicating that individuals with SLC 6A3-9 genotypes were significantly less likely to be smokers.
Journal ArticleDOI
Genetic testing in families with hereditary nonpolyposis colon cancer.
Caryn Lerman,Chanita Hughes,Bruce J. Trock,Ronald E. Myers,David Main,Aba Bonney,Mohammad Reza Abbaszadegan,Anne E. Harty,Barbara Franklin,Jane F. Lynch,Henry T. Lynch +10 more
TL;DR: Despite having significantly elevated risks of developing colon cancer, a relatively small proportion of HNPCC family members are likely to use genetic testing, and barriers to test acceptance may include less formal education and the presence of depression symptoms.
Journal ArticleDOI
What you don't know can hurt you: adverse psychologic effects in members of BRCA1-linked and BRCA2-linked families who decline genetic testing.
Caryn Lerman,Chanita Hughes,Stephen J. Lemon,David Main,Carrie Snyder,Carolyn Durham,Steven Narod,Henry T. Lynch +7 more
TL;DR: In BRCA1/2-linked families, persons with high levels of cancer-related stress who decline genetic testing may be at risk for depression and should be monitored for potential adverse effects.
Journal ArticleDOI
Prophylactic Surgery Decisions and Surveillance Practices One Year Following BRCA1/2 Testing
Caryn Lerman,Chanita Hughes,Robert T. Croyle,David Main,Carolyn Durham,Carrie Snyder,Aba Bonney,Jane F. Lynch,Steven A. Narod,Henry T. Lynch +9 more
TL;DR: The vast majority of BRCA1/2 carriers may not opt for prophylactic surgery, and many do not adhere to surveillance recommendations, suggesting greater attention to risk communication and medical decision-making is warranted.