David McMullin

TL;DR: Screening of simplified cell culture systems may aid the discovery of novel biomarkers in clinical neurovascular injury, and the high-ranking candidate thrombospondin-1 was further explored in human plasma.

TL;DR: Clinical studies and molecular mapping of the circulatory landscape of this multi-organ disease will both be necessary in order to better individualize clinical treatment for a condition affecting more than a quarter of the world's population.

TL;DR: It is demonstrated that tPA treatment changes the plasma degradomic profiles in acute stroke patients, which supports the feasibility of performing pharmacoproteomics at the bedside, which may ultimately allow us to dissect mechanisms of thrombolysis-related therapeutic efficacy in stroke.

TL;DR: It is found that during pregnancy and post-partum, PFO is associated with complications affecting multiple organs, including the brain, heart and lung, and the three principal complications reported are stroke, pulmonary emboli and myocardial infarction.

TL;DR: Among patients undergoing PFO closure to prevent future stroke, the presence of residual shunt, particularly a moderate or large residualShunt, was associated with an increased risk for stroke or TIA recurrence.