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David N. Brindley
Researcher at University of Alberta
Publications - 254
Citations - 12951
David N. Brindley is an academic researcher from University of Alberta. The author has contributed to research in topics: Phosphatidate & Phosphatidate phosphatase. The author has an hindex of 65, co-authored 248 publications receiving 12403 citations. Previous affiliations of David N. Brindley include University of Nottingham.
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Journal ArticleDOI
Three Mammalian Lipins Act as Phosphatidate Phosphatases with Distinct Tissue Expression Patterns
TL;DR: The results establish the three mammalian lipin proteins as PAP1 enzymes and explain the biochemical basis for lipodystrophy in the lipin-1-deficient fld mouse.
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High-fat feeding alters both basal and stress-induced hypothalamic-pituitary-adrenal activity in the rat
Beth Tannenbaum,David N. Brindley,Gloria Shaffer Tannenbaum,Gloria Shaffer Tannenbaum,Mary F. Dallman,M. Dawn McArthur,Michael J. Meaney +6 more
TL;DR: Dietary fat intake acts as a background form of chronic stress, elevating basal B levels and enhancing HPA responses to stress, suggesting support for the specificity of the effects on the HPA axis.
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Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis.
Denis English,Zachary Welch,A. Thomas Kovala,Kevin A. Harvey,Olga V. Volpert,David N. Brindley,Joe G.N. Garcia +6 more
TL;DR: Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis.
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(n-3) PUFA Alter Raft Lipid Composition and Decrease Epidermal Growth Factor Receptor Levels in Lipid Rafts of Human Breast Cancer Cells
TL;DR: The results indicate that (n-3) FA modify the lipid composition of membrane rafts and alter EGFR signaling in a way that decreases the growth of breast tumors.
Journal ArticleDOI
Possible connections between stress, diabetes, obesity, hypertension and altered lipoprotein metabolism that may result in atherosclerosis.
David N. Brindley,Yves Rolland +1 more
TL;DR: Observations provide a partial explanation for the metabolic changes that can accompany the risk factors and clarify why they interact in promoting atherosclerosis.