O
Olga V. Volpert
Researcher at Northwestern University
Publications - 97
Citations - 14069
Olga V. Volpert is an academic researcher from Northwestern University. The author has contributed to research in topics: Angiogenesis & Neovascularization. The author has an hindex of 56, co-authored 96 publications receiving 13552 citations.
Papers
More filters
Journal ArticleDOI
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
TL;DR: Transfection assays indicate that, in fibroblasts, wild-type p53 inhibits angiogenesis through regulation of TSP-1 synthesis.
Journal ArticleDOI
Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.
David W. Dawson,Olga V. Volpert,Paul R. Gillis,Susan E. Crawford,Han Xu,William F. Benedict,Noel P. Bouck +6 more
TL;DR: The results suggest that PEDF may be of therapeutic use, especially in retinopathies where pathological neovascularization compromises vision and leads to blindness.
Journal ArticleDOI
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
Benilde Jiménez,Olga V. Volpert,Susan E. Crawford,Maria Febbraio,Roy L. Silverstein,Noel P. Bouck +5 more
TL;DR: Results indicate that thrombospondin-1, and possibly other broad-spectrum natural inhibitors of angiogenesis, act in vivo by inducing receptor-mediated apoptosis in activated microvascular endothelial cells.
Journal ArticleDOI
Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity
Sara S. Tolsma,Olga V. Volpert,Deborah J. Good,William A. Frazier,Peter J. Polverini,Noel P. Bouck +5 more
TL;DR: The results suggest that the large TSP1 molecule employs at least two different structural domains and perhaps two different mechanisms to accomplish a single physiological function, the inhibition of neovascularization.
Journal ArticleDOI
Maspin is an angiogenesis inhibitor.
TL;DR: The data suggest that the tumor suppressor activity of maspin may depend in large part on its ability to inhibit angiogenesis and raise the possibility that maspIn and similar serpins may be excellent leads for the development of drugs that modulateAngiogenesis.