D
David Polak
Researcher at Hebrew University of Jerusalem
Publications - 60
Citations - 1461
David Polak is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Porphyromonas gingivalis & Fusobacterium nucleatum. The author has an hindex of 14, co-authored 50 publications receiving 1042 citations. Previous affiliations of David Polak include Hadassah Medical Center.
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Journal ArticleDOI
Primary prevention of periodontitis: managing gingivitis
Iain L. C. Chapple,Fridus van der Weijden,Christof Doerfer,David Herrera,Lior Shapira,David Polak,Phoebus N. Madianos,Anna Louropoulou,Eli E. Machtei,Nikos Donos,Henry Greenwell,Ari J. Van Winkelhoff,Bahar Kuru,Nicole B. Arweiler,Wim Teughels,Mario Aimetti,Ana Molina,Eduardo Montero,Filippo Graziani +18 more
TL;DR: Data support the belief that professionally administered plaque control significantly improves gingival inflammation and lowers plaque scores, with some evidence that reinforcement of oral hygiene provides further benefit.
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Mouse model of experimental periodontitis induced by Porphyromonas gingivalis/Fusobacterium nucleatum infection: bone loss and host response
David Polak,Asaf Wilensky,Lior Shapira,Amal Halabi,Dita Goldstein,Ervin I. Weiss,Yael Houri-Haddad +6 more
TL;DR: The results suggest that oral infection of mice with a mixture of P. gingivalis and F. nucleatum may be superior to mono-infection models of experimental periodontitis, and induces a stronger inflammatory response compared with that observed upon infection with either bacterium alone.
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An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes.
David Polak,Lior Shapira +1 more
TL;DR: The elevated pro-inflammatory factors in the gingiva of patients with poorly controlled diabetes suggest a biological pathway that may aggravate periodontitis.
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Direct Recognition of Fusobacterium nucleatum by the NK Cell Natural Cytotoxicity Receptor NKp46 Aggravates Periodontal Disease
Stella Chaushu,Asaf Wilensky,Chamutal Gur,Lior Shapira,Moran Elboim,Gili Halftek,David Polak,Hagit Achdout,Gilad Bachrach,Ofer Mandelboim +9 more
TL;DR: The present study provides the first evidence that NCR1 and NKp46 directly recognize a periodontal pathogen and that this interaction influences the outcome of F. nucleatum-mediated periodontitis.
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Diabetes as a risk factor for periodontal disease-plausible mechanisms
TL;DR: The evidence supports the role of several pathogenic mechanisms in the path of true causal comorbidity between poorly controlled diabetes and periodontitis, but further research is needed to better understand these mechanisms and to explore other mechanisms.