G
Gil Y. Melmed
Researcher at Cedars-Sinai Medical Center
Publications - 347
Citations - 8960
Gil Y. Melmed is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Inflammatory bowel disease & Medicine. The author has an hindex of 43, co-authored 264 publications receiving 7392 citations. Previous affiliations of Gil Y. Melmed include Dartmouth–Hitchcock Medical Center & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Genome-wide association identifies multiple ulcerative colitis susceptibility loci
Dermot P.B. McGovern,Agnes Gardet,Leif Törkvist,Philippe Goyette,Jonah Essers,Kent D. Taylor,Benjamin M. Neale,Rick Twee-Hee Ong,Caroline Lagacé,Chun Li,Todd Green,Christine Stevens,Claudine Beauchamp,Phillip Fleshner,Marie Carlson,Mauro D'Amato,Jonas Halfvarson,Martin L. Hibberd,Mikael Lördal,Leonid Padyukov,Angelo Andriulli,Elisabetta Colombo,Anna Latiano,Orazio Palmieri,Edmond Jean Bernard,Colette Deslandres,Daan W. Hommes,Dirk J. de Jong,Pieter C. F. Stokkers,Rinse K. Weersma,Yashoda Sharma,Mark S. Silverberg,Judy H. Cho,Jing Wu,Jing Wu,Kathryn Roeder,Steven R. Brant,L Phillip Schumm,Richard H. Duerr,Marla Dubinsky,Nicole L. Glazer,Talin Haritunians,Andrew Ippoliti,Gil Y. Melmed,David S. Siscovick,Eric A. Vasiliauskas,Stephan R. Targan,Vito Annese,Cisca Wijmenga,Sven Pettersson,Jerome I. Rotter,Jerome I. Rotter,Ramnik J. Xavier,Mark J. Daly,John D. Rioux,Mark Seielstad +55 more
TL;DR: Two distinct genome-wide association studies of ulcerative colitis are presented and their joint analysis with a previously published scan shows that roughly half of the known Crohn's disease associations are shared with ulceratives colitis, thereby providing insight into disease pathogenesis.
Journal ArticleDOI
Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut
Gil Y. Melmed,Lisa S. Thomas,Nahee Lee,Samuel Y. Tesfay,Katie Lukasek,Kathrin S. Michelsen,Yuehua Zhou,Bing Hu,Moshe Arditi,Maria T. Abreu +9 more
TL;DR: The relative absence of TLR2 protein expression by IEC and high level of Tollip expression may be important in preventing chronic proinflammatory cytokine secretion in response to commensal Gram-positive bacteria in the gut.
Journal ArticleDOI
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
Dermot P.B. McGovern,Matthew Jones,Kent D. Taylor,Kristin D. Marciante,Xiaofei Yan,Marla Dubinsky,Andrew Ippoliti,Eric A. Vasiliauskas,Dror Berel,Carrie Derkowski,Deb Dutridge,Phil Fleshner,David Q. Shih,Gil Y. Melmed,Emebet Mengesha,Lily King,Sheila Pressman,Talin Haritunians,Xiuqing Guo,Stephan R. Targan,Jerome I. Rotter +20 more
TL;DR: In this paper, the authors performed a genome-wide association study (GWAS) in 896 Crohn's disease (CD) cases and 3204 healthy controls all of Caucasian origin as defined by multidimensional scaling.
Journal ArticleDOI
ACG Clinical Guideline: Preventive Care in Inflammatory Bowel Disease.
TL;DR: Health maintenance issues addressed in this guideline include identification, safety and appropriate timing of vaccinations, screening for osteoporosis, cervical cancer, melanoma and non-melanoma skin cancer as well as identification of depression and anxiety and smoking cessation.