David R. Janero

TL;DR: The conclusion is reached that MDA determination and the TBA test can offer, at best, a narrow and somewhat empirical window on the complex process of lipid peroxidation.

TL;DR: Mechanisms for the production of pro-inflammatory eicosanoid mediators contributing to inflammation are described and promising options for the prevention of inflammatory mediator formation and the therapeutic inhibition of pain and inflammation are summarized.

TL;DR: Most tissues (except erythrocytes) produce free NO at rates that are maximal under hypoxia and that correlate robustly with each tissue's capacity for mitochondrial oxygen consumption, as well as comparing the kinetics of NO release before and after ferricyanide addition in tissue homogenates to mathematical models of \batchmode.

TL;DR: Pharmacologic investigation of vitamin E (and synthetic, vitamin E-like antioxidants) in nutritional and hyperlipidemic animal models of spontaneous atherosclerosis is required to establish whether any atherosclerotic impact is associated with vitamin E and, if so, what the mechanistic basis of the therapeutic benefit is.

TL;DR: The biochemical pathology of H2O2 overload on cardiomyocyte carbohydrate metabolism has implications for post-ischemic cardiac bioenergetics and function and establishes that specific aspects of heart muscle hexose catabolism are H 2O2-sensitive injury targets.