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David R. Raleigh
Researcher at University of California, San Francisco
Publications - 171
Citations - 5380
David R. Raleigh is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 28, co-authored 109 publications receiving 3676 citations. Previous affiliations of David R. Raleigh include University of Chicago.
Papers
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Journal ArticleDOI
Tight Junction Pore and Leak Pathways: A Dynamic Duo
TL;DR: An integrated model in which dynamic regulation of tight junction protein interactions determines barrier function is proposed, which is not absolute but is selectively permeable and able to discriminate between solutes on the basis of size and charge.
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Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
Amanda M. Marchiando,Le Shen,W. Vallen Graham,Christopher R. Weber,Brad T. Schwarz,Jotham R. Austin,David R. Raleigh,Yanfang Guan,Alastair J.M. Watson,Marshall H. Montrose,Jerrold R. Turner +10 more
TL;DR: Although tight junction morphology is not obviously affected by TNF, this proinflammatory cytokine promotes internalization of occludin, resulting in disrupted barrier function within the intestine.
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Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions.
David R. Raleigh,Amanda M. Marchiando,Yong Zhang,Le Shen,Hiroyuki Sasaki,Hiroyuki Sasaki,Yingmin Wang,Manyuan Long,Jerrold R. Turner +8 more
TL;DR: Analysis using phylogenetic, expression profiling, microscopic, and functional approaches show that marvelD3, occludin, and tricellulin are related and have distinct but overlapping functions at the tight junction.
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Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity
Christopher R. Weber,David R. Raleigh,Liping Su,Le Shen,Erika A. Sullivan,Yingmin Wang,Jerrold R. Turner +6 more
TL;DR: It is concluded that reversible, MLCK-dependent permeability increases cause mucosal immune activation that, in turn, feeds back on the tight junction to establish long-lasting barrier defects.
Journal ArticleDOI
MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function
Dan Yu,Amanda M. Marchiando,Christopher R. Weber,David R. Raleigh,Yingmin Wang,Le Shen,Jerrold R. Turner +6 more
TL;DR: A critical role is demonstrated for the ZO-1 ABR in barrier function and it is suggested that MLCK-dependent Zo-1 exchange is essential to this mechanism of barrier regulation.