David R. Rowley

TL;DR: The stromal microenvironment in human prostate cancer is altered compared with normal stroma and exhibits features of a wound repair stroma, and it is suggested that TGF-beta1 is a candidate regulator of reactive stroma during prostate cancer progression.

TL;DR: Reactive stroma in prostate cancer and granulation tissue in wound repair show similar biological responses and processes that are predicted to promote cancer progression.

TL;DR: This is the first study to demonstrate that nonepithelial-reactive stroma elements in prostate cancer tumors can be used as prognostic indicators and add to the concept that tumors are not purely epithelial and the tumor-re active stroma must be considered an important biological component of the cancer.

TL;DR: In this paper, the authors identify and evaluate candidate genes expressed in prostate stromal cells responsible for differential tumor-promoting activity and show that connective tissue growth factor (CTGF) was expressed at low levels in nontumor-promising prostate stroma cells and was constitutively expressed in tumor-proto-prostate cells.

TL;DR: The biology of reactive stroma in cancer is similar to the more predictable biology of the stroma compartment during wound repair at sites where the epithelial barrier function is breached and a stromal response is generated.