Showing papers by "David R. Rubinow published in 2003"
TL;DR: Data suggest that parturition-related endocrine changes are causally implicated in PPD in a vulnerable subgroup of women, and a role for changes in estradiol and progesterone in precipitating mood symptoms among women with PPD is suggested.
421 citations
TL;DR: It is demonstrated that women with PMS, when symptomatic, appear to have an abnormal response to progesterone and, furthermore, do not display the HPA axis abnormalities characteristic of major depression.
Abstract: Previous studies in animals indicate that reproductive steroids are potent modulators of the hypothalamic-pituitary-adrenal (HPA) axis, a physiologic system that is typically dysregulated in affective disorders, such as major depression. Determination of the role of reproductive steroids in HPA axis regulation in humans is of importance when attempting to understand the pathophysiology of premenstrual syndrome (PMS), a disorder characterized by affective symptoms during the luteal phase of the menstrual cycle. We performed two studies using treadmill exercise stress testing to determine the effect of menstrual cycle phase and diagnosis on the HPA axis in women with PMS and controls and the role of gonadal steroids in HPA axis modulation in control women. The results of these studies indicate that women with PMS fail to show the normal increased HPA axis response to exercise during the luteal phase and that progesterone, not estradiol, produces increased HPA axis response to treadmill stress testing in control women. These data demonstrate that women with PMS, when symptomatic, appear to have an abnormal response to progesterone and, furthermore, do not display the HPA axis abnormalities characteristic of major depression.
168 citations
TL;DR: Mood and behavioral effects observed during AAS use may in part reflect secondary hormonal changes, and acute high-dose MT administration acutely suppresses the reproductive axis and significantly impacts thyroid axis balance without a consistent effect on pituitary-adrenal hormones.
97 citations
TL;DR: This work has presented the first physiological evidence for an abnormal brain response to progesterone in PMS, and women with PMS showed relative facilitation.
81 citations
TL;DR: No single operational threshold of the phenomenal features maximizes selection of both symptomatic and asymptomatic cycles, largely consequent to the ubiquity of post menstrual symptoms and premenstrual "interference" even in women without PMS.
63 citations
TL;DR: Data suggest that dimorphisms in cell survival may underlie enhanced neuronal survival (or decreased apoptosis) in female brain and the appearance of sex-related differences at cellular and signaling levels in cortical neuronal cultures demonstrates that the effects of gender are not limited to parts of the brain mediating reproduction.
58 citations
TL;DR: Mood variability in women with perimenopausal depression may reflect episodic alterations in ovarian function that are best detected by longitudinal study designs.
Abstract: OBJECTIVE: Despite reports of estradiol’s therapeutic efficacy in perimenopausal depression, the relationship between ovarian function and mood in perimenopausal depression remains unclear. The purpose of this study was to examine changes in mood and pituitary-ovarian axis function in women exhibiting perimenopausal depression. METHOD: Depression ratings (from the Center for Epidemiologic Studies—Depression Scale [CES-D Scale]) and follicle-stimulating hormone (FSH) plasma levels of depressed perimenopausal women (N=110) attending a menopause clinic were obtained at baseline and after a 6-week screening period. RESULTS: Eighteen women experienced an improvement in depression (50% decline in CES-D Scale scores) at week 6, which was associated with a significant decrease in FSH plasma levels (baseline: mean=73.3 IU/liter [SD=42.0]; week 6: mean=42.2 IU/liter [SD=28.6]). Similarly, those subjects experiencing a 50% drop in FSH plasma levels had significant decreases in CES-D Scale scores (baseline: mean=23.3...
54 citations
TL;DR: Low baseline CSF somatostatin in depression may be associated with response to nimmodipine, which in turn may be related to the ability of nimodipine to increaseCSF som atostatin.
17 citations
Journal Article•
8 citations