D
David R. Snodgrass
Publications - 8
Citations - 135
David R. Snodgrass is an academic researcher. The author has contributed to research in topics: Rotavirus & Immune system. The author has an hindex of 6, co-authored 8 publications receiving 129 citations.
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Passive immunity in calf diarrhea: vaccination with K99 antigen of enterotoxigenic Escherichia coli and rotavirus.
TL;DR: Serum and milk antibodies to K99 and rotavirus in cows vaccinated with either dose of oil vaccine were significantly increased until at least 28 days after calving, and a combined enterotoxigenic E. coli-rotavirus vaccine may prove useful in preventing some outbreaks of calf diarrhea.
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Effect of oral rotavirus/iscom vaccines on immune responses in gnotobiotic lambs.
Laurens A.H. van Pinxteren,Maureen G. Bruce,I Campbell,Ann Wood,C.J. Clarke,Anna Bellman,Bror Morein,David R. Snodgrass +7 more
TL;DR: Both Th1-like and Th2-like immune responses were induced in the group receiving the VP6 vaccine as seen by significantly increased expressions of IFNgamma and IL-6 in the jejunal Peyer's patch together with an increased percentage of CD8+ T cells in the intestine and rotavirus-specific antibodies at mucosal surfaces.
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Experimental infection of non-human primates with a human rotavirus isolate.
TL;DR: Data indicate that baboon and vervet monkeys may be useful models for human rotav virus infection and for pre-clinical evaluation of rotavirus candidate vaccines.
Journal ArticleDOI
Stimulation of rotavirus IgA, IgG and neutralising antibodies in baboon milk by parenteral vaccination
David R. Snodgrass,I Campbell,Jason M. Mwenda,Gerald K. Chege,M A Suleman,Bror Morein,C.A. Hart +6 more
TL;DR: Because of the endemic nature of human rotaviral infections, similar maternal vaccinations have potential as a means of increasing milk antibodies to a level at which they may be protective to infants.
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Intestinal cellular immunity after primary rotavirus infection.
TL;DR: Analysis of lymphocyte surface antigens indicated that different sub-populations of lymphocytes were responding in the various lymphoid tissues; a majority of CD4+ cells was observed in the mesenteric lymph nodes, whereas B cells predominated in the ileal Peyer's patches.