D
David R. Spring
Researcher at University of Cambridge
Publications - 316
Citations - 15404
David R. Spring is an academic researcher from University of Cambridge. The author has contributed to research in topics: Quorum sensing & Chemistry. The author has an hindex of 56, co-authored 298 publications receiving 13238 citations. Previous affiliations of David R. Spring include AstraZeneca & University of Oxford.
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Journal ArticleDOI
Fluorescent chemosensors for Zn2
TL;DR: This tutorial review will classify zinc chemosensors based on receptor types based on the biological significance of zinc combined with the simplicity and high sensitivity of fluorescence assays.
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Zn2+-triggered amide tautomerization produces a highly Zn2+-selective, cell-permeable, and ratiometric fluorescent sensor.
Zhaochao Xu,Zhaochao Xu,Kyung Hwa Baek,Ha Na Kim,Jingnan Cui,Xuhong Qian,David R. Spring,Injae Shin,Juyoung Yoon +8 more
TL;DR: A novel amide-containing receptor for Zn(2+), combined with a naphthalimide fluorophore, termed ZTRS, which showed excellent selectivity for zinc ions over most competitive HTM ions with an enhanced fluorescence as well as a red-shift in emission from 483 to 514 nm.
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Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules
TL;DR: Diversity-oriented synthesis (DOS) aims to generate structural diversity in an efficient manner through the screening of small-molecule libraries for the discovery of novel, biologically interesting small molecules.
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Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways.
TL;DR: This work has shown that quorum sensing enhances the survival prospects of the bacteria because a coordinated attack on the host is only made when the bacterial population reaches a high population density, increasing the likelihood that the hosts defenses will be successfully overwhelmed.
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Arene C–H functionalisation using a removable/modifiable or a traceless directing group strategy
TL;DR: An overview of recent advances in this emerging field which have dramatically increased the synthetic applicability of C-H functionalisation processes is given.