D
David Salzman
Researcher at Yale University
Publications - 15
Citations - 345
David Salzman is an academic researcher from Yale University. The author has contributed to research in topics: Transistor & Semiconductor. The author has an hindex of 9, co-authored 15 publications receiving 319 citations. Previous affiliations of David Salzman include University of California, Los Angeles.
Papers
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Journal ArticleDOI
SNPing cancer in the bud: microRNA and microRNA-target site polymorphisms as diagnostic and prognostic biomarkers in cancer.
David Salzman,Joanne B. Weidhaas +1 more
TL;DR: Findings suggest single nucleotide polymorphisms in microRNAs and microRNA-target sites impact microRNA biology and associate with cancer risk, treatment response and outcome, and the possible future of utilizing these SNPs as diagnostic and prognostic markers in the clinic are discussed.
Journal ArticleDOI
miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage
David Salzman,Kotoka Nakamura,Sunitha Nallur,Michelle Dookwah,Chanatip Metheetrairut,Frank J. Slack,Frank J. Slack,Joanne B. Weidhaas +7 more
TL;DR: It is shown for the first time that there is a pool of mature miR-34 in cells that lacks a 5′-phosphate and is inactive, and a novel mechanism of rapid miRNA activation in response to environmental stimuli occurring at the mature miRNA level is revealed.
Journal ArticleDOI
A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy.
Zenia Saridaki,Zenia Saridaki,Joanne B. Weidhaas,Heinz-Josef Lenz,Pierre Laurent-Puig,Bart Jacobs,Jef De Schutter,Wendy De Roock,David Salzman,Wu Zhang,Dongyun Yang,Camilla Pilati,Olivier Bouché,Hubert Piessevaux,Sabine Tejpar +14 more
TL;DR: LCS6-variant patients with metastatic colorectal cancer have an excellent response to anti-EGFR mAb monotherapy, without any benefit from the addition of chemotherapy, and warrant further prospective confirmation.
Patent
Surface passivation for III-V compound semiconductors
TL;DR: In this article, a structure and method of fabrication for improving surface passivation of III-V compound semiconductors is described, which enables microelectronic devices including diode, transistor, solar cell, photodetector, and CCDs with superior performance.
Patent
Wide dynamic range photodetector
Eric S. Harmon,David Salzman +1 more
TL;DR: In this paper, a Geiger mode avalanche photodiodes (APDs) and conventional semiconductor photodetectors with poor noise floors are combined to achieve high efficiency detection of single photons and a wide dynamic range.