D
David Sibley
Researcher at Washington University in St. Louis
Publications - 7
Citations - 243
David Sibley is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Toxoplasma gondii & Major histocompatibility complex. The author has an hindex of 4, co-authored 7 publications receiving 234 citations.
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Journal ArticleDOI
The amphipathic alpha-helices of the toxoplasma protein GRA2 mediate post-secretory membrane association
Journal ArticleDOI
High-Resolution Typing of Toxoplasma gondii Using Microsatellite Loci
C. R. Blackston,Jitender P. Dubey,E. Dotson,Chunlei Su,P. Thulliez,David Sibley,Tovi Lehmann +6 more
TL;DR: 6 new variable loci were described here, including a minisatellite and 5 microsatellites, that were more polymorphic than allozymes, restriction fragment length polymorphisms, and sequence variation in introns and revealed, for the first time, substantial within-lineage variation that was over 6-fold higher than that detected by other markers.
Journal ArticleDOI
Replication of Toxoplasma gondii, but Not Trypanosoma cruzi, Is Regulated in Human Fibroblasts Activated with Gamma Interferon: Requirement of a Functional JAK/STAT Pathway
Isabela P. Ceravolo,Andréa Carla Leite Chaves,Cláudio A. Bonjardim,David Sibley,Alvaro J. Romanha,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli +6 more
TL;DR: The findings indicate the essential requirement of the JAK/STAT pathway for the induction of high levels of INDO mRNA, tryptophan degradation, and the anti-Toxoplasma activity inside human nonprofessional phagocytic cells.
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Role of cytokines and major histocompatibility complex restriction in mouse resistance to infection with a natural recombinant strain (type I-III) of Toxoplasma gondii.
Blima Fux,Blima Fux,Cibele V. Rodrigues,Ricardo Wagner Portela,Neide M. Silva,Chunlei Su,David Sibley,Ricardo Wagner de Almeida Vitor,Ricardo T. Gazzinelli +8 more
TL;DR: The results indicate that resistance to cyst formation and toxoplasmic encephalitis induced during infection with P-Br is not primarily controlled by the MHC haplotype d, as previously reported for type II strains of T. gondii.
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Cellular microbiology — a research agenda and an emerging discipline
TL;DR: The aim of Cellular Microbiology is to provide a comprehensive forum for papers elucidating the biology of microbial±host cell interactions at the cellular and organismal levels to address questions related to the cellular, immunological and molecular process involved when two competing organisms meet and interact.