R
Ricardo T. Gazzinelli
Researcher at Oswaldo Cruz Foundation
Publications - 360
Citations - 30133
Ricardo T. Gazzinelli is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Immune system & Trypanosoma cruzi. The author has an hindex of 86, co-authored 340 publications receiving 28233 citations. Previous affiliations of Ricardo T. Gazzinelli include Federal University of São Paulo & University of Massachusetts Medical School.
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Journal ArticleDOI
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
TL;DR: IL-12 has a major effect on the inductive phase of T-cell priming by enhancing commitment to IFN-gamma production and thus can profoundly influence the state of immunity that develops.
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal
Ricardo T. Gazzinelli,Maria Wysocka,Sara Hieny,Tanya Scharton-Kersten,Allen W. Cheever,Ralf Kühn,Werner Müller,Giorgio Trinchieri,Alan Sher +8 more
TL;DR: In vitro depletion experiments indicated that CD4+ lymphocytes are the major source of the latter cytokine in the spleen cell populations, and in vivo depletion with anti-CD4 Abs protected the IL-10 KO mice from parasite-induced mortality.
Journal Article
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.
Ricardo T. Gazzinelli,Maria Wysocka,Sara Hieny,Tanya Scharton-Kersten,Allen W. Cheever,Ralf Kühn,Werner Müller,Giorgio Trinchieri,Alan Sher +8 more
TL;DR: In this article, the function of IL-10 synthesis during early infection with the intracellular protozoan Toxoplasma gondii was examined in mice inoculated with an avirulent parasite strain (ME-49).
Journal ArticleDOI
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.
TL;DR: The data argue that IL-12 is required for the T-cell-independent triggering of NK cells by intracellular parasites and that the cytokine may be useful for inducing this protective pathway in immunodeficient hosts.
Journal Article
IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.
TL;DR: Results indicate that the induction of IL-10 may be an important strategy by which parasites evade IFN-gamma-dependent, cell-mediated immune destruction by blocking the ability of that lymphokine to activate macrophages.