D
David Valdecanas
Researcher at University of Texas MD Anderson Cancer Center
Publications - 33
Citations - 1833
David Valdecanas is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Radiation therapy. The author has an hindex of 18, co-authored 33 publications receiving 1527 citations. Previous affiliations of David Valdecanas include Ohio State University.
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Journal ArticleDOI
PDL1 Regulation by p53 via miR-34
Maria Angelica Cortez,Cristina Ivan,David Valdecanas,Xiaohong Wang,Heidi J. Peltier,Yuping Ye,Luiz H. Araujo,David P. Carbone,Konstantin Shilo,Dipak Giri,Kevin Kelnar,Desiree Martin,Ritsuko Komaki,Daniel R. Gomez,Sunil Krishnan,George A. Calin,Andreas G. Bader,James W. Welsh +17 more
TL;DR: The results suggest that delivery of miRNAs with standard therapies, such as XRT, may represent a novel therapeutic approach for lung cancer, and identify a novel mechanism by which tumor immune evasion is regulated by p53/miR-34/PDL1 axis.
Journal ArticleDOI
Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy.
Xiaohong Wang,Jonathan E. Schoenhals,Ailin Li,David Valdecanas,Huiping Ye,Fenglin Zang,Chad Tang,Ming Tang,Chang Gong Liu,Xiuping Liu,Sunil Krishnan,James P. Allison,Padmanee Sharma,Patrick Hwu,Ritsuko Komaki,Willem W. Overwijk,Daniel R. Gomez,Joe Y. Chang,Stephen M. Hahn,Maria Angelica Cortez,James W. Welsh +20 more
TL;DR: Localized radiotherapy induced IFNβ production, thereby elevating MHC class I expression on both parental and resistant tumor cells and restoring the responsiveness of resistant tumors to anti-PD-1 therapy, and adjuvant radiotherapy can overcome resistance.
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Therapeutic Delivery of miR-200c Enhances Radiosensitivity in Lung Cancer
Maria Angelica Cortez,David Valdecanas,Xiaochun Zhang,Yanai Zhan,Vikas Bhardwaj,George A. Calin,Ritsuko Komaki,Dipak Giri,Caio C. Quini,Tatiana Wolfe,Heidi J. Peltier,Andreas G. Bader,John V. Heymach,Raymond E. Meyn,James W. Welsh +14 more
TL;DR: It is found that miR-200c overexpression increased cellular radiosensitivity by direct regulation of the oxidative stress response genes PRDX2, GAPB/Nrf2, and SESN1 in ways that inhibits DNA double-strand breaks repair, increase levels of reactive oxygen species, and upregulate p21.
Journal ArticleDOI
CpG Oligodeoxynucleotide Enhances Tumor Response to Radiation
Luka Milas,Kathryn A. Mason,Hisanori Ariga,Nancy Hunter,Robert Neal,David Valdecanas,Arthur M. Krieg,John K. Whisnant +7 more
TL;DR: Results show that CpG ODNs are potent enhancers of tumor radioresponse and as such have potential to improve clinical radiotherapy.
Journal Article
Targeting Toll-like Receptor 9 with CpG Oligodeoxynucleotides Enhances Tumor Response to Fractionated Radiotherapy
Kathryn A. Mason,Hisanori Ariga,Robert Neal,David Valdecanas,Nancy Hunter,Arthur M. Krieg,John K. Whisnant,Luka Milas +7 more
TL;DR: CpG oligodeoxynucleotides are highly potent enhancers of tumor response to both single-dose and fractionated radiation and as such have potential to improve clinical radiotherapy.