M
Ming Tang
Researcher at Harvard University
Publications - 65
Citations - 3500
Ming Tang is an academic researcher from Harvard University. The author has contributed to research in topics: Chromatin & Enhancer. The author has an hindex of 19, co-authored 62 publications receiving 2018 citations. Previous affiliations of Ming Tang include University of Florida & Howard Hughes Medical Institute.
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Journal ArticleDOI
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
A. Gordon Robertson,Juliann Shih,Juliann Shih,Christina Yau,Ewan A. Gibb,Junna Oba,Karen Mungall,Julian M. Hess,Vladislav Uzunangelov,Vonn Walter,Vonn Walter,Ludmila Danilova,Tara M. Lichtenberg,Melanie H. Kucherlapati,Patrick K. Kimes,Ming Tang,Alexander V Penson,Özgün Babur,Rehan Akbani,Christopher A. Bristow,Katherine A. Hoadley,Lisa Iype,Matthew T. Chang,Matthew T. Chang,Mohamed H. Abdel-Rahman,Adrian Ally,J. Todd Auman,Miruna Balasundaram,Saianand Balu,Christopher C. Benz,Rameen Beroukhim,Inanc Birol,Tom Bodenheimer,Jay Bowen,Reanne Bowlby,Denise Brooks,Rebecca Carlsen,Colleen M. Cebulla,Andrew D. Cherniack,Andrew D. Cherniack,Lynda Chin,Juok Cho,Eric Chuah,Sudha Chudamani,Carrie Cibulskis,Kristian Cibulskis,Leslie Cope,Sarah E. Coupland,Timothy Defreitas,John A. Demchok,Laurence Desjardins,Noreen Dhalla,Bita Esmaeli,Ina Felau,Martin L. Ferguson,Scott Frazer,Stacey Gabriel,Julie M. Gastier-Foster,Nils Gehlenborg,Mark Gerken,Jeffrey E. Gershenwald,Gad Getz,Klaus G. Griewank,Elizabeth A. Grimm,D. Neil Hayes,Apurva M. Hegde,David I. Heiman,Carmen Helsel,Shital Hobensack,Robert A. Holt,Alan P. Hoyle,Xin Hu,Carolyn M. Hutter,Martine J. Jager,Stuart R. Jefferys,Corbin D. Jones,Steven J.M. Jones,Cyriac Kandoth,Katayoon Kasaian,Jaegil Kim,Raju Kucherlapati,Eric S. Lander,Michael S. Lawrence,Alexander J. Lazar,Semin Lee,Kristen M. Leraas,Pei Lin,Jia Liu,Wen-Bin Liu,Laxmi Lolla,Yiling Lu,Yussanne Ma,Harshad S. Mahadeshwar,Odette Mariani,Marco A. Marra,Michael Mayo,Sam Meier,Shaowu Meng,Matthew Meyerson,Piotr A. Mieczkowski,Gordon B. Mills,Richard A. Moore,Lisle E. Mose,Andrew J. Mungall,Bradley A. Murray,Rashi Naresh,Michael S. Noble,Angeliki Pantazi,Michael Parfenov,Peter J. Park,Joel S. Parker,Charles M. Perou,Todd Pihl,Robert Pilarski,Alexei Protopopov,Amie Radenbaugh,Karan Rai,Nilsa C. Ramirez,Xiaojia Ren,Sheila Reynolds,Jeffrey Roach,Sergio Roman-Roman,Jason Roszik,Sara Sadeghi,Gordon Saksena,Xavier Sastre,Dirk Schadendorf,Jacqueline E. Schein,Lynn Schoenfield,Steven E. Schumacher,Jonathan G. Seidman,Sahil Seth,Geetika Sethi,Margi Sheth,Yan Shi,Carol L. Shields,Ilya Shmulevich,Janae V. Simons,Arun D. Singh,Payal Sipahimalani,Tara Skelly,Heidi J. Sofia,Matthew G. Soloway,Xingzhi Song,Marc-Henri Stern,Joshua M. Stuart,Qiang Sun,Huandong Sun,Angela Tam,Donghui Tan,Jiabin Tang,Roy Tarnuzzer,Barry S. Taylor,Nina Thiessen,Vesteinn Thorsson,Kane Tse,Umadevi Veluvolu,Roel G.W. Verhaak,Doug Voet,Yunhu Wan,Zhining Wang,John N. Weinstein,Matthew D. Wilkerson,Michelle D. Williams,Lisa Wise,Scott E. Woodman,Tina Wong,Ye Wu,Liming Yang,Lixing Yang,Jean C. Zenklusen,Jiashan Zhang,Hailei Zhang,Erik Zmuda +173 more
TL;DR: Within D3-UM, EIF1AX- and SRSF2/SF3B1-mutant tumors have distinct somatic copy number alterations and DNA methylation profiles, providing insight into the biology of these low- versus intermediate-risk clinical mutation subtypes.
Journal ArticleDOI
Systematic analysis of telomere length and somatic alterations in 31 cancer types
Floris P. Barthel,Wei Wei,Ming Tang,Emmanuel Martinez-Ledesma,Xin Hu,Xin Hu,Samirkumar B. Amin,Samirkumar B. Amin,Kadir C. Akdemir,Sahil Seth,Xingzhi Song,Qianghu Wang,Tara M. Lichtenberg,Jian Hu,Jianhua Zhang,Siyuan Zheng,Roel G.W. Verhaak +16 more
TL;DR: This analysis integrates TERT abnormalities, telomerase activity and genomic alterations with telomere length in cancer.
Journal ArticleDOI
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer
Wenting Liao,Michael J. Overman,Adam T. Boutin,Xiaoying Shang,Di Zhao,Prasenjit Dey,Jiexi Li,Guocan Wang,Zhengdao Lan,Jun Li,Ming Tang,Shan Jiang,Xingdi Ma,Peiwen Chen,Riham Katkhuda,Krittiya Korphaisarn,Deepavali Chakravarti,Andrew Chang,Denise J. Spring,Qing Chang,Jianhua Zhang,Dipen M. Maru,Dean Y. Maeda,John A. Zebala,Scott Kopetz,Y. Alan Wang,Ronald A. DePinho +26 more
TL;DR: The KRAS∗-IRF2-CXCL3- CXCR2 axis provides a framework for patient selection and combination therapies to enhance the effectiveness of ICB therapy in CRC and shows increased responsiveness to anti-PD-1 therapy.
Journal ArticleDOI
Landscape of EGFR-Dependent and -Independent Resistance Mechanisms to Osimertinib and Continuation Therapy Beyond Progression in EGFR-Mutant NSCLC.
Xiuning Le,Sonam Puri,Marcelo V. Negrao,Monique B. Nilsson,Jacqulyne P. Robichaux,Theresa A. Boyle,J. Kevin Hicks,Katherine L. Lovinger,Emily Roarty,Waree Rinsurongkawong,Ming Tang,Huiying Sun,Yasir Elamin,Lara Lacerda,Jeff Lewis,Jack A. Roth,Stephen G. Swisher,J. Jack Lee,William N. William,Bonnie S. Glisson,Jianjun Zhang,Vassiliki A. Papadimitrakopoulou,Jhanelle E. Gray,John V. Heymach +23 more
TL;DR: Continuation of osimertinib after progression, alone or in conjunction with radiotherapy, may provide prolonged clinical benefit in selected patients and is associated with diverse, predominantly EGFR-independent genomic alterations.
Journal ArticleDOI
TumorFusions: An integrative resource for cancer-associated transcript fusions
Xin Hu,Xin Hu,Qianghu Wang,Ming Tang,Floris P. Barthel,Samirkumar B. Amin,Kosuke Yoshihara,Frederick Lang,Emmanuel Martinez-Ledesma,Soo Hyun Lee,Siyuan Zheng,Roel G.W. Verhaak +11 more
TL;DR: TumorFusions is described, a data portal that catalogues 20 731 gene fusions detected in 9966 well characterized cancer samples and 648 normal specimens from The Cancer Genome Atlas (TCGA), which spans 33 cancer types in TCGA.