D
David Verhoeven
Researcher at Iowa State University
Publications - 38
Citations - 1631
David Verhoeven is an academic researcher from Iowa State University. The author has contributed to research in topics: Immune system & Virus. The author has an hindex of 15, co-authored 37 publications receiving 1477 citations. Previous affiliations of David Verhoeven include University of California, Davis & California National Primate Research Center.
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Journal ArticleDOI
Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
Manuela Raffatellu,Renato L. Santos,David Verhoeven,Michael D. George,R. Paul Wilson,Sebastian E. Winter,Ivan Godinez,Sumathi Sankaran,Tatiane A. Paixão,Melita A. Gordon,Jay K. Kolls,Satya Dandekar,Andreas J. Bäumler +12 more
TL;DR: It is shown that simian immunodeficiency virus (SIV) infection results in depletion of T helper type 17 (TH17) cells in the ileal mucosa of rhesus macaques, thereby impairing mucosal barrier functions to S. typhimurium dissemination.
Journal ArticleDOI
Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of Human Immunodeficiency Virus Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection
Moraima Guadalupe,Sumathi Sankaran,Michael D. George,Elizabeth Reay,David Verhoeven,Barbara L. Shacklett,Jason Flamm,Jacob A. Wegelin,Thomas P Prindiville,Satya Dandekar +9 more
TL;DR: The findings suggest that the discordance in CD4+ T-cell restoration between GALT and peripheral blood during therapy can be attributed to the incomplete viral suppression and increased immune activation and inflammation that may prevent restoration of CD4- T cells and the gut microenvironment.
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Memory CD4 T Cells Direct Protective Responses to Influenza Virus in the Lungs through Helper-Independent Mechanisms
TL;DR: It is demonstrated that memory CD4 T cells specific for H1N1 influenza virus directed protective responses to influenza virus challenge through intrinsic effector mechanisms, resulting in enhanced viral clearance, recovery from sublethal infection, and full protection from lethal challenge.
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Antiviral Therapy during Primary Simian Immunodeficiency Virus Infection Fails To Prevent Acute Loss of CD4+ T Cells in Gut Mucosa but Enhances Their Rapid Restoration through Central Memory T Cells
TL;DR: Central memory CD4+ T-cell levels and qualitative antiviral CD8-cell responses, independent of viral suppression, were the immune correlates of gut mucosal immune restoration during ART.
Journal ArticleDOI
DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate.
Mary Premenko-Lanier,Paul A. Rota,Gary Rhodes,David Verhoeven,Dan H. Barouch,Nicholas W. Lerche,Norman L. Letvin,William J. Bellini,Michael B. McChesney +8 more
TL;DR: It is shown for the first time that DNA vaccination can protect a newborn primate from the high-level viremia that correlates with severe measles, even in the presence of maternal antibody.