D
David W. Lafleur
Researcher at Human Genome Sciences
Publications - 92
Citations - 3612
David W. Lafleur is an academic researcher from Human Genome Sciences. The author has contributed to research in topics: Gene & Fusion protein. The author has an hindex of 25, co-authored 90 publications receiving 3485 citations.
Papers
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Journal ArticleDOI
BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator
Paul A. Moore,Ornella Belvedere,Amy Orr,Krystyna Pieri,David W. Lafleur,Ping Feng,Daniel R. Soppet,Meghan Charters,Reiner L. Gentz,David Parmelee,Yuling Li,Olga Galperina,Judith Giri,Viktor Roschke,Bernardetta Nardelli,Jeffrey Carrell,Svetlana Sosnovtseva,Wilbert Greenfield,Steven M. Ruben,Henrik S. Olsen,James Fikes,David M. Hilbert +21 more
TL;DR: The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation, and its expression on human monocytes could be up-regulated by interferon-gamma.
Journal ArticleDOI
Tumor Necrosis Factor (TNF) Receptor Superfamily Member TACI Is a High Affinity Receptor for TNF Family Members APRIL and BLyS
Youmei Wu,Dana Bressette,Jeff Carrell,Thomas Kaufman,Ping Feng,Kara Taylor,Yuxiang Gan,Yun Hee Cho,Andy Garcia,Elisa Gollatz,Donna Dimke,David W. Lafleur,Thi Sau Migone,Bernardetta Nardelli,Ping Wei,Steve Ruben,Stephen Ullrich,Henrik S. Olsen,Palanisamy Kanakaraj,Paul A. Moore,Kevin P. Baker +20 more
TL;DR: It is concluded that TACI is a receptor for BLyS and APRIL and the implications for B-cell biology are discussed.
Journal ArticleDOI
Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes
TL;DR: The preferential expression of IRf-7 in lymphoid cells (the cell type that expresses IFNA) suggests that IRF-7 may play a critical role in regulating the IFNA gene expression.
Journal ArticleDOI
Interferon-κ, a Novel Type I Interferon Expressed in Human Keratinocytes
David W. Lafleur,Bernardetta Nardelli,Tatiana Tsareva,Don Mather,Ping Feng,Mark Semenuk,Kara Taylor,Markus Buergin,Diana Chinchilla,Viktor Roshke,Guoxian Chen,Steven M. Ruben,Paula M. Pitha,Timothy A. Coleman,Paul A. Moore +14 more
TL;DR: Interferon-κ therefore defines a novel subclass of type I interferon that is expressed in keratinocytes and expands the repertoire of known proteins mediating host defense.
Patent
186 human secreted proteins
Steven M. Ruben,Craig A. Rosen,Daniel R. Soppet,Kenneth C. Carter,Daniel P. Bednarik,Gregory A. Endress,Guo-Liang Yu,Jian Ni,Ping Feng,Paul E. Young,John M. Greene,Ann M. Ferrie,D. Duan,Jing-Shan Hu,Kimberly A. Florence,Henrik S. Olsen,Carrie L. Fischer,Reinhard Ebner,Laurie A. Brewer,Paul A. Moore,Yanggu Shi,David W. Lafleur,Yi Li,Zhizhen Zeng,Hla Kyaw +24 more
TL;DR: The present paper relates to 186 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins as discussed by the authors, and further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel proteins.