P
Paula M. Pitha
Researcher at Johns Hopkins University
Publications - 212
Citations - 18879
Paula M. Pitha is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Interferon & Gene. The author has an hindex of 70, co-authored 212 publications receiving 18298 citations. Previous affiliations of Paula M. Pitha include Salk Institute for Biological Studies & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
Katherine A. Fitzgerald,Daniel C. Rowe,Betsy J. Barnes,Daniel R. Caffrey,Alberto Visintin,Eicke Latz,Brian G. Monks,Paula M. Pitha,Douglas T. Golenbock +8 more
TL;DR: These studies suggest that TRIF and TRAM both function in LPS-TLR4 signaling to regulate the MyD88-independent pathway during the innate immune response to LPS.
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Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation
TL;DR: Interestingly, virus infection resulted in the association of IRF-3 with the CREB binding protein (CBP) coactivator, as detected by coimmunoprecipitation with anti-CBP antibody, an interaction mediated by the C-terminal domains of both proteins.
Journal Article
E-Cadherin Expression Is Silenced by DNA Hypermethylation in Human Breast and Prostate Carcinomas
Jeremy R. Graff,James G. Herman,Rena G. Lapidus,Hemi Chopra,Rosa Xu,David F. Jarrard,William B. Isaacs,Paula M. Pitha,Nancy E. Davidson,Stephen B. Baylin +9 more
TL;DR: The data demonstrate that frequent loss of E-cad expression in human breast and prostate carcinomas results from hypermethylation of the E- cad promoter region.
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Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7
Jongdae Lee,Tsung-Hsien Chuang,Vanessa Redecke,Liping She,Paula M. Pitha,Dennis A. Carson,Eyal Raz,Howard B. Cottam +7 more
TL;DR: Evidence is presented that guanosine analogs activate immune cells via TLR7 by a pathway that requires endosomal maturation, and the B cell-stimulating and antiviral activities of the guanosin analogs may be explained by theirTLR7-activating capacity.
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The growing family of interferon regulatory factors
TL;DR: Understanding the molecular mechanisms by which the IRFs affect these important cellular events and IFN expression will contribute to a greater understanding of events leading to various viral, immune and malignant disease states and will suggest novel strategies for antiviral and immune modulatory therapy.