David W. Seccombe

TL;DR: Clinical needs have been identified for standardization of urine collection methods, urine albumin and creatinine measurements based on a complete reference system, reporting of test results, and reference intervals for the ACR.

TL;DR: A computerized Hoffmann method for indirect estimation of reference intervals using stored test results is proved to be accurate and reproducible.

TL;DR: Serum and urine levels of free carnitine and its renal clearance decreased during the fast, however, the serum concentration and urinary excretion of acylcarnitines increased during the same interval, and a significant negative correlation was found between serum levels offree L-carn itine and beta-hydroxybutyrate and free fatty acids during thefast.

TL;DR: The premature infant has a limited capacity for fatty acid oxidation as discussed by the authors showed that solutions commonly used for intravenous feedings in the newborn infant contain no carnitine and infants maintained on this solution have significantly lower total, free, and acylcarnitine levels as compared to when they are fed orally with expressed human milk or a proprietary formula.

TL;DR: This study shows that solutions commonly used for intravenous feedings in the newborn infant contain no carnitine, indicating that the exogenous supply of Carnivaline to the premature infant may have a significant influence on the ability to stimulate optimal fatty acid oxidation.