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David W. Seccombe

Researcher at University of British Columbia

Publications -  49
Citations -  1628

David W. Seccombe is an academic researcher from University of British Columbia. The author has contributed to research in topics: Carnitine & Digoxin. The author has an hindex of 20, co-authored 48 publications receiving 1526 citations. Previous affiliations of David W. Seccombe include Vancouver General Hospital.

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Overexpression of acyl-coA binding protein and its effects on the flux of free fatty acids in McA-RH 7777 cells.

TL;DR: A role for ACBP is suggested in the partitioning of fatty acids between esterification reactions leading to the formation of neutral lipids and β-oxidation, and ACBP may play a regulatory role by influencing this important branch point in intermediary lipid metabolism.
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The effects of 3‐hydroxy‐3‐methylglutaryl‐CoA reductase inhibition on tissue levels of carnitine and carnitine acyltransferase activity in the rabbit

TL;DR: Carnitine acetyltransferase was unaffected by the treatment of an HMG-CoA reductase inhibitor (lovastatin), whereas there was a significant increase in the activity of CPT in the liver and heart.
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National Survey of Adult and Pediatric Reference Intervals in Clinical Laboratories across Canada: A Report of the CSCC Working Group on Reference Interval Harmonization

TL;DR: It is evident that there is a critical lack of harmonization in laboratory reference intervals, particularly for the pediatric population, as well as pediatric and adult reference intervals currently used in clinical practice across Canada.
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Point Status of lipid and lipoprotein standardization

TL;DR: Standardized cholesterol and triglyceride concentrations, determined in multiple large epidemiological and clinical studies, have been instrumental to the National Cholesterol Education Program panels that have assessed the lipoprotein values associated with risk of coronary disease, and have determined the cutpoints that are now used extensively by physicians to guide diagnosis and treatment of individual patients.
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Digoxin-like immunoreactivity, displacement of ouabain and inhibition of Na+/K+ ATPase by four steroids known to be increased in essential hypertension.

TL;DR: It is concluded that these steroids may contribute to DLIS as isolated from hypertensive patients, but it is unlikely that they would be of physiological significance in the etiology of EH unless they were to accumulate and act synergistically within vascular wall smooth muscle tissues.