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David W. Seccombe
Researcher at University of British Columbia
Publications - 49
Citations - 1628
David W. Seccombe is an academic researcher from University of British Columbia. The author has contributed to research in topics: Carnitine & Digoxin. The author has an hindex of 20, co-authored 48 publications receiving 1526 citations. Previous affiliations of David W. Seccombe include Vancouver General Hospital.
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Journal ArticleDOI
Current Issues in Measurement and Reporting of Urinary Albumin Excretion
W. Greg Miller,David E. Bruns,Glen L. Hortin,Sverre Sandberg,Kristin M. Aakre,Matthew J. McQueen,Yoshihisa Itoh,John C. Lieske,David W. Seccombe,Graham R D Jones,David M. Bunk,Gary C. Curhan,Andrew S. Narva +12 more
TL;DR: Clinical needs have been identified for standardization of urine collection methods, urine albumin and creatinine measurements based on a complete reference system, reporting of test results, and reference intervals for the ACR.
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Establishing reference intervals for clinical laboratory test results: is there a better way?
TL;DR: A computerized Hoffmann method for indirect estimation of reference intervals using stored test results is proved to be accurate and reproducible.
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Effect of fasting on free and esterified carnitine levels in human serum and urine: Correlation with serum levels of free fatty acids and β-hydroxybutyrate
TL;DR: Serum and urine levels of free carnitine and its renal clearance decreased during the fast, however, the serum concentration and urinary excretion of acylcarnitines increased during the same interval, and a significant negative correlation was found between serum levels offree L-carn itine and beta-hydroxybutyrate and free fatty acids during thefast.
Journal Article
Plasma carnitine levels during intravenous feeding of the neonate.
TL;DR: The premature infant has a limited capacity for fatty acid oxidation as discussed by the authors showed that solutions commonly used for intravenous feedings in the newborn infant contain no carnitine and infants maintained on this solution have significantly lower total, free, and acylcarnitine levels as compared to when they are fed orally with expressed human milk or a proprietary formula.
Journal ArticleDOI
Plasma carnitine levels during intravenous feeding of the neonate
TL;DR: This study shows that solutions commonly used for intravenous feedings in the newborn infant contain no carnitine, indicating that the exogenous supply of Carnivaline to the premature infant may have a significant influence on the ability to stimulate optimal fatty acid oxidation.