D
David Y. Zhang
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 177
Citations - 10391
David Y. Zhang is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Cancer & Nucleic acid. The author has an hindex of 47, co-authored 173 publications receiving 9062 citations. Previous affiliations of David Y. Zhang include University of Maryland, College Park & Harvard University.
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Journal ArticleDOI
Enzyme-Free Nucleic Acid Logic Circuits
TL;DR: The design and experimental implementation of DNA-based digital logic circuits using single-stranded nucleic acids as inputs and outputs are reported, suggesting applications in biotechnology and bioengineering.
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Control of DNA Strand Displacement Kinetics Using Toehold Exchange
David Y. Zhang,Erik Winfree +1 more
TL;DR: This work improves the understanding of the kinetics of nucleic acid reactions and will be useful in the rational design of dynamic DNA and RNA circuits and nanodevices.
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Engineering entropy-driven reactions and networks catalyzed by DNA.
TL;DR: A design strategy is introduced that allows a specified input oligonucleotide to catalyze the release of a specified output oligon nucleotide, which in turn can serve as a catalyst for other reactions, which provides an amplifying circuit element that is simple, fast, modular, composable, and robust.
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Optimizing the specificity of nucleic acid hybridization
TL;DR: Analytically derived the thermodynamic properties of a hybridization probe that would enable near-optimal single-base discrimination and perform robustly across diverse temperature, salt and concentration conditions.
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Fibrosis-dependent mechanisms of hepatocarcinogenesis.
David Y. Zhang,Scott L. Friedman +1 more
TL;DR: Clarifying fibrosis‐dependent tumorigenic mechanisms will help rationalize antifibrotic therapies as a strategy to prevent and treat HCC.