D
Dawn A. Parsell
Researcher at Howard Hughes Medical Institute
Publications - 9
Citations - 2022
Dawn A. Parsell is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 7, co-authored 9 publications receiving 1979 citations.
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Journal ArticleDOI
Protein disaggregation mediated by heat-shock protein Hsp104.
TL;DR: Hspl04 functions in a manner not previously described for other heat-shock proteins: it mediates the resolubilization of heat-inactivated luciferase from insoluble aggregates.
Journal ArticleDOI
18 Heat Shock Proteins and Stress Tolerance
Dawn A. Parsell,Susan Lindquist +1 more
TL;DR: Induced thermotolerance is observed in virtually every organism studied, and mild heat pretreatments elicit resistance not just to high temperatures, but to an extraordinary variety of other stresses.
Journal ArticleDOI
Hsp104 is a highly conserved protein with two essential nucleotide-binding sites.
TL;DR: Hsp104 is a member of the highly conserved ClpA/ClpB protein family first identified in Escherlchla coli and that additional heat-inducible members of this family are present in Schizosaccharomyces pombe and in mammals.
Journal ArticleDOI
The role of heat-shock proteins in thermotolerance
TL;DR: The role of heat-shock proteins (hsps) in thermotolerance was examined in the budding yeast Saccharomyces cerevisiae and in the fruit fly Drosophila melanogaster, suggesting that the primary function of hsp 104 is to rescue proteins from denaturation rather than to degrade them once they have been denatured.
Journal ArticleDOI
The ATPase Activity of Hsp104, Effects of Environmental Conditions and Mutations
Eric C. Schirmer,Christine Queitsch,Anthony S. Kowal,Dawn A. Parsell,Susan Lindquist,Susan Lindquist +5 more
TL;DR: Either the functions of the two NBDs in ClpA and Hsp104 have been reversed or both contribute to ATP hydrolysis and oligomerization in a complex manner that can be idiosyncratically affected by such mutations.