Dean A. Baker

TL;DR: Population modeling and cage experiments indicate that a CRISPR-Cas9 construct targeting one of these loci meets the minimum requirement for a gene drive targeting female reproduction in an insect population, which could expedite the development of gene drives to suppress mosquito populations to levels that do not support malaria transmission.

TL;DR: This study presents transcription profiles for ~82% of annotated Anopheles genes in dissected adult male and female tissues and provides information on the relative strength and specificity of gene expression in several somatic and reproductive tissues, isolated from a single strain grown under uniform conditions.

TL;DR: Fundamental aspects of egg development and gender-biased transcription can be derived from the time-series experiment and it is believed that this dataset will facilitate further exploration of the developmental and evolutionary characteristics of oogenesis as well as the nature of reproductive arrest in Drosophila.

TL;DR: It is shown that transcriptional variation between common laboratory strains of Drosophila can differ dramatically due to sexual dimorphism, and much of this variation reflects sex-specific challenges associated with divergent physiological trade-offs, morphology and regulatory pathways operating within males and females.

TL;DR: An extensive set of HE variants with novel DNA cleavage specificities are created using an integrated experimental and computational approach and unanticipated context-dependence between bases is observed.