K
Kyros Kyrou
Researcher at Imperial College London
Publications - 20
Citations - 2379
Kyros Kyrou is an academic researcher from Imperial College London. The author has contributed to research in topics: Population & Anopheles gambiae. The author has an hindex of 10, co-authored 20 publications receiving 1691 citations.
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Journal ArticleDOI
A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae
Andrew Hammond,Roberto Galizi,Kyros Kyrou,Alekos Simoni,Carla Siniscalchi,Dimitris Katsanos,Matthew Gribble,Dean A. Baker,Eric Marois,Steven Russell,Austin Burt,Nikolai Windbichler,Andrea Crisanti,Tony Nolan +13 more
TL;DR: Population modeling and cage experiments indicate that a CRISPR-Cas9 construct targeting one of these loci meets the minimum requirement for a gene drive targeting female reproduction in an insect population, which could expedite the development of gene drives to suppress mosquito populations to levels that do not support malaria transmission.
Journal ArticleDOI
A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes
Kyros Kyrou,Andrew Hammond,Roberto Galizi,Nace Kranjc,Austin Burt,Andrea Beaghton,Tony Nolan,Andrea Crisanti +7 more
TL;DR: It is found that CRISPR–Cas9-targeted disruption of the intron 4–exon 5 boundary aimed at blocking the formation of functional AgdsxF did not affect male development or fertility, whereas females homozygous for the disrupted allele showed an intersex phenotype and complete sterility.
Journal ArticleDOI
The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito.
Andrew Hammond,Kyros Kyrou,Marco Bruttini,Ace North,Roberto Galizi,Xenia Karlsson,Nace Kranjc,Francesco M. Carpi,Romina D'Aurizio,Andrea Crisanti,Tony Nolan +10 more
TL;DR: These findings represent the first documented example of selection for resistance to a synthetic gene drive and lead to important design recommendations and considerations in order to mitigate for resistance in future gene drive applications.
Journal ArticleDOI
A CRISPR-Cas9 sex-ratio distortion system for genetic control.
Roberto Galizi,Andrew Hammond,Kyros Kyrou,Chrysanthi Taxiarchi,Chrysanthi Taxiarchi,Federica Bernardini,Samantha M. O’Loughlin,Philippos Aris Papathanos,Tony Nolan,Nikolai Windbichler,Andrea Crisanti +10 more
TL;DR: A CRISPR-Cas9 sex distortion system that targets ribosomal sequences restricted to the member species of the Anopheles gambiae complex is described that is broadly applicable for the species-specific control of any pest or vector species with an XY sex-determination system by targeting sequences exclusive to the female sex chromosome.
Journal ArticleDOI
A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
Alekos Simoni,Andrew Hammond,Andrew Hammond,Andrea Beaghton,Roberto Galizi,Roberto Galizi,Chrysanthi Taxiarchi,Kyros Kyrou,Dario Meacci,Matthew Gribble,Giulia Morselli,Austin Burt,Tony Nolan,Tony Nolan,Andrea Crisanti,Andrea Crisanti +15 more
TL;DR: A male-biased sex-distorter gene drive (SDGD) is reported in the human malaria vector Anopheles gambiae and is predicted to have a quicker impact on female mosquito populations than previously developed gene drives targeting female fertility.