Matthew Gribble

TL;DR: Population modeling and cage experiments indicate that a CRISPR-Cas9 construct targeting one of these loci meets the minimum requirement for a gene drive targeting female reproduction in an insect population, which could expedite the development of gene drives to suppress mosquito populations to levels that do not support malaria transmission.

TL;DR: A male-biased sex-distorter gene drive (SDGD) is reported in the human malaria vector Anopheles gambiae and is predicted to have a quicker impact on female mosquito populations than previously developed gene drives targeting female fertility.

TL;DR: The results show that drongos can evade the frequency-dependent constraints that typically limit deception payoffs through flexible variation of their alarm calls.

TL;DR: In this paper, the authors show that regulation of nuclease expression is as important as the choice of target site when developing a robust homing-based gene drive for population suppression.

TL;DR: Three new gene drives designed to restrict spatio-temporal nuclease expression by using novel regulatory sequences are described, demonstrating in laboratory-contained population experiments that these gene drives show remarkably improved invasion dynamics compared to the first generation drives.