Screening for breast cancer.

Early diagnosis of breast cancer

Ratiometric luminescent sensors have been of considerable interest to the chemo/biosensor with the ability of providing a precisely quantitative and qualitative analysis. The main strategies for ge...

Recent advances in ratiometric luminescence sensors

Molecular diversity assessed amongst high dry rhizome recovery Ginger germplasm (Zingiber officinale Roscoe) from NE-India using RAPD and ISSR markers

Owing to the worldwide demand for cinnamon spices, true cinnamon (Cinnamomum verum) powder is often being adulterated with another inferior quality of cinnamon known as cassia cinnamon (Cinnamomum ...

Rapid authentication measurement of cinnamon powder using FT-NIR and FT-IR spectroscopic techniques

There have been substantial advancements in optical spectroscopy-based imaging techniques in recent years. These developments can potentially herald a transformational change in the diagnostic path...

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Optical spectroscopy-based imaging techniques for the diagnosis of breast cancer: A novel approach

Development of an effective and efficient DNA isolation method for Cinnamomum species

Currently, the confirmation of diagnosis of breast cancer is made by microscopic examination of an ultra-thin slice of a needle biopsy specimen This slice is conventionally formalin-fixed and stained with hematoxylin-eosin and visually examined under a light microscope This process is labor-intensive and requires highly skilled doctors (pathologists) In this paper, we report a novel tool based on near-infrared spectroscopy (Spectral-IRDx) which is a portable, non-contact, and cost-effective system and could provide a rapid and accurate diagnosis of cancer The Spectral-IRDx tool performs absorption spectroscopy at near-infrared (NIR) wavelengths of 850, 935, and 1060 nm We measure normalized detected voltage (Vdn) with the tool in 10 deparaffinized breast biopsy tissue samples, 5 of which were cancer (C) and 5 were normal (N) tissues The difference in Vdn at 935 nm and 1060 nm between cancer and normal tissues is statistically significant with p -values of 00038 and 00022 respectively Absorption contrast factor (N/C) of 1303, 1551, and 145 are observed for 850, 935, and 1060 nm respectively The volume fraction contrast (N/C) of lipids and collagens are reported as 128 and 110 respectively Higher absorption contrast factor (N/C) and volume fraction contrast (N/C) signifies higher concentration of lipids in normal tissues as compared to cancerous tissues, a basis for delineation These preliminary results support the envisioned concept for noninvasive and noncarcinogenic NIR-based breast cancer diagnostic platform, which will be tested using a larger number of samples

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Towards a Portable Platform Integrated With Multispectral Noncontact Probes for Delineating Normal and Breast Cancer Tissue Based on Near-Infrared Spectroscopy

Deb Baruah

Papers

Optical spectroscopy-based imaging techniques for the diagnosis of breast cancer: A novel approach

Development of an effective and efficient DNA isolation method for Cinnamomum species

Towards a Portable Platform Integrated With Multispectral Noncontact Probes for Delineating Normal and Breast Cancer Tissue Based on Near-Infrared Spectroscopy