D
Debaraj Mukherjee
Researcher at Academy of Scientific and Innovative Research
Publications - 124
Citations - 1690
Debaraj Mukherjee is an academic researcher from Academy of Scientific and Innovative Research. The author has contributed to research in topics: Catalysis & Aryl. The author has an hindex of 22, co-authored 124 publications receiving 1369 citations. Previous affiliations of Debaraj Mukherjee include Council of Scientific and Industrial Research & Wayne State University.
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Importance and synthesis of benzannulated medium-sized and macrocyclic rings (BMRs)
TL;DR: In this article, the authors highlight the importance of benzannulated medium-sized and macrocyclic rings (BMRs) and the strategies developed over the years for their synthesis.
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A Novel MMP-2 Inhibitor 3-azidowithaferin A (3- azidoWA) Abrogates Cancer Cell Invasion and Angiogenesis by Modulating Extracellular Par-4
Bilal Rah,Hina Amin,Khalid Yousuf,Sheema Khan,Gayatri Jamwal,Debaraj Mukherjee,Anindya Goswami +6 more
TL;DR: The in vitro result strongly suggests that sub-toxic doses of 3-azidoWA enhanced the secretion of extracellular Par-4 that abolished secretory MMP-2 expression and activity and implied that 3-AZidoWA attenuated internal phospho-ERK and phospho -Akt expression in a dose dependent manner might play a key role in inhibition of mouse angiogenesis by 3-razidoWA.
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PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells.
Bilal Rah,Reyaz ur Rasool,Debasis Nayak,Syed Khalid Yousuf,Debaraj Mukherjee,Lekha Dinesh Kumar,Anindya Goswami +6 more
TL;DR: Evidence is provided that 3-AWA is a strong anticancer candidate to abrogate protective autophagy and enhanced chemosensitivity by sensitizing prostate cancer cells to apoptosis through induction of PAWR endorsing its therapeutic potential.
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Detailed account on activation mechanisms of ruthenium coordination complexes and their role as antineoplastic agents.
TL;DR: The physicochemical processes which are responsible for the selectivity of Ru complexes toward cancer cells over the normal cells are summarized and some emerging concepts regarding lack of innertness of Ru(III) complexes vis-à-vis Ru(II) species are made.
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Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential.
Syed Khalid Yousuf,Rabiya Majeed,Mudassier Ahmad,Payare L. Sangwan,Basant Purnima,A.K. Saxsena,Krishan Avtar Suri,Debaraj Mukherjee,Subhash C. Taneja +8 more
TL;DR: Modifications of 3-azido analogue with various alkynes under Husigen's cycloaddition conditions generated a variety of triazole derivatives with reduced cytotoxicity.