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Deborah B. Loeb
Publications - 3
Citations - 3628
Deborah B. Loeb is an academic researcher. The author has contributed to research in topics: Hereditary hemochromatosis & Hemochromatosis. The author has an hindex of 3, co-authored 3 publications receiving 3560 citations.
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal ArticleDOI
A 1.1-mb transcript map of the hereditary hemochromatosis locus
David A. Ruddy,Gregory S. Kronmal,Vincent K. Lee,Gabriel Mintier,Leah Quintana,Rodolfo Domingo,Nicole C. Meyer,Alivelu Irrinki,Erin E. McClelland,Amy Fullan,Felipa A. Mapa,Theodore Moore,Winston Thomas,Deborah B. Loeb,Cyrus L. Harmon,Zenta Tsuchihashi,Roger K. Wolff,Randall C. Schatzman,John N. Feder +18 more
TL;DR: An analysis of the four approaches for gene finding and conclude that direct selection provides the most effective probes for cDNA screening, and that as much as 30% of ESTs in this 1.1-Mb region may be derived from noncoding genomic DNA.
Journal ArticleDOI
A haplotype and linkage disequilibrium analysis of the hereditary hemochromatosis gene region
TL;DR: The genotypic data was analyzed with a multilocus maximum likelihood method ( DISMULT) and a single point method (DISLAMB), both written to analyze data generated from multi-allelic markers, and the recombination rate appears to be lower than expected centromeric of the HFE gene.