R
Roger K. Wolff
Researcher at University of Utah
Publications - 168
Citations - 13684
Roger K. Wolff is an academic researcher from University of Utah. The author has contributed to research in topics: Colorectal cancer & Population. The author has an hindex of 49, co-authored 166 publications receiving 12890 citations. Previous affiliations of Roger K. Wolff include Howard Hughes Medical Institute.
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
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Variable number of tandem repeat (VNTR) markers for human gene mapping
Yusuke Nakamura,Mark Leppert,Peter O'Connell,Roger K. Wolff,Tom Holm,Melanie Culver,Cindy Martin,Esther Fujimoto,Mark Hoff,Erika Kumlin,Ray White +10 more
TL;DR: Ten oligomeric sequences derived from the tandem repeat regions of the myoglobin gene, the zeta-globin pseudogene, the insulin gene, and the X-gene region of hepatitis B virus were used to develop a series of single-copy probes that revealed new, highly polymorphic genetic loci whose allele sizes reflected variation in the number of tandem repeats.
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Poor Survival Associated with the BRAF V600E Mutation in Microsatellite-Stable Colon Cancers
Wade S. Samowitz,Carol Sweeney,Jennifer S. Herrick,Hans Albertsen,Theodore R. Levin,Maureen A. Murtaugh,Roger K. Wolff,Martha L. Slattery +7 more
TL;DR: It is concluded that the BRAF V600E mutation in microsatellite-stable colon cancer is associated with a significantly poorer survival in stages 2 to 4 colon cancer but has no effect on the excellent prognosis of micros satellite-unstable tumors.
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Evaluation of a Large, Population-Based Sample Supports a CpG Island Methylator Phenotype in Colon Cancer
Wade S. Samowitz,Hans Albertsen,Jennifer S. Herrick,Theodore R. Levin,Carol Sweeney,Maureen A. Murtaugh,Roger K. Wolff,Martha L. Slattery +7 more
TL;DR: The evaluation of a large, population-based sample of individuals with colon cancer strongly supports the biologic relevance of CIMP in colon cancer, however, the presence or absence of microsatellite instability has a major effect on the expression of this phenotype.
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Association of Smoking, CpG Island Methylator Phenotype, and V600E BRAF Mutations in Colon Cancer
Wade S. Samowitz,Hans Albertsen,Carol Sweeney,Jennifer S. Herrick,Bette J. Caan,Kristin E. Anderson,Roger K. Wolff,Martha L. Slattery +7 more
TL;DR: Previously identified associations between smoking and colon cancer, whether microsatellite unstable or stable, appear to be explained by the association of smoking with CIMP and BRAF mutations.