D
Deborah L. Birx
Researcher at Henry M. Jackson Foundation for the Advancement of Military Medicine
Publications - 6
Citations - 2442
Deborah L. Birx is an academic researcher from Henry M. Jackson Foundation for the Advancement of Military Medicine. The author has contributed to research in topics: Antibody & Virus. The author has an hindex of 5, co-authored 6 publications receiving 2361 citations. Previous affiliations of Deborah L. Birx include Walter Reed Army Institute of Research.
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Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies.
John R. Mascola,Gabriela Stiegler,Thomas C. VanCott,Hermann Katinger,Calvin B. Carpenter,Chris E. Hanson,Holly Beary,Deborah Hayes,Sarah S. Frankel,Deborah L. Birx,Mark G. Lewis +10 more
TL;DR: It is demonstrated that antibodies can affect transmission and subsequent disease course after vaginal SHIV-challenge, and the data begin to define the type of antibody response that could play a role in protection against mucosal transmission of HIV-1.
Journal ArticleDOI
DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
Boonrat Tassaneetrithep,Boonrat Tassaneetrithep,Timothy Burgess,Angela Granelli-Piperno,Christine Trumpfheller,Jennifer S. Finke,Wellington Sun,Michael A. Eller,Kovit Pattanapanyasat,S Sarasombath,Deborah L. Birx,Ralph M. Steinman,Sarah J. Schlesinger,Mary A. Marovich +13 more
TL;DR: Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells primarily at the immature stage of their differentiation and DC-SIGN, a C-type lectin, may be considered as a new target for designing therapies that block dengue infection.
Journal ArticleDOI
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
John R. Mascola,Gabriela Stiegler,Thomas C. VanCott,Hermann Katinger,Calvin B. Carpenter,Chris E. Hanson,Holly Beary,Deborah Hayes,Sarah S. Frankel,Deborah L. Birx,Mark G. Lewis +10 more
TL;DR: In this paper, the development of the human immunodeficiency virus-1 (HIV-1)/simian immunoviciency virus (SIV) chimeric virus macaque model (SHIV) permits the in vivo evaluation of anti-HIV1 envelope glycoprotein immune responses.
Journal ArticleDOI
Neutralizing Monoclonal Antibodies Block Human Immunodeficiency Virus Type 1 Infection of Dendritic Cells and Transmission to T Cells
Sarah S. Frankel,Sarah S. Frankel,Ralph M. Steinman,Nelson L. Michael,Silvia Ratto Kim,Nina Bhardwaj,Melissa Pope,Mark K. Louder,Philip K. Ehrenberg,Paul W. H. I. Parren,Dennis R. Burton,Hermann Katinger,Thomas C. VanCott,Merlin L. Robb,Deborah L. Birx,John R. Mascola +15 more
TL;DR: Investigation of the ability of three well-characterized neutralizing MAbs to block HIV-1 infection of human DC suggests that neutralizing antibodies could interrupt the initial events associated with mucosal transmission and regional spread of HIV- 1.
Short communication Induction of HIV-specific functional immune responses by a multiclade HIV-1 DNA vaccine candidate in healthy Ugandans
Michael A. Eller,Leigh Anne Eller,Marc S. Opollo,Benson J. Ouma,Peter O. Oballah,Lynee M. Galley,Chitraporn Karnasuta,Silvia Ratto Kim,Merlin L. Robb,Nelson L. Michael,Hannah Kibuuka,Fred Wabwire-Mangen,Barney S. Graham,Deborah L. Birx,Mark de Souza,Josephine H. Cox +15 more
TL;DR: It is demonstrated that immunization with DNA alone induces CTL and lymphoproliferative responses in a population that will participate in a phase IIb study evaluating HIV-1 DNA priming followed by boosting with a replication-defective recombinant adenovirus vector.