S
Sarah S. Frankel
Researcher at Armed Forces Institute of Pathology
Publications - 14
Citations - 2514
Sarah S. Frankel is an academic researcher from Armed Forces Institute of Pathology. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 11, co-authored 14 publications receiving 2466 citations. Previous affiliations of Sarah S. Frankel include Henry M. Jackson Foundation for the Advancement of Military Medicine & Walter Reed Army Institute of Research.
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Journal ArticleDOI
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies.
John R. Mascola,Gabriela Stiegler,Thomas C. VanCott,Hermann Katinger,Calvin B. Carpenter,Chris E. Hanson,Holly Beary,Deborah Hayes,Sarah S. Frankel,Deborah L. Birx,Mark G. Lewis +10 more
TL;DR: It is demonstrated that antibodies can affect transmission and subsequent disease course after vaginal SHIV-challenge, and the data begin to define the type of antibody response that could play a role in protection against mucosal transmission of HIV-1.
Journal ArticleDOI
Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid.
Sarah S. Frankel,Bruce M. Wenig,Allen P. Burke,Poonam Mannan,Lester D.R. Thompson,Susan L. Abbondanzo,Ann Marie Nelson,Melissa Pope,Ralph M. Steinman +8 more
TL;DR: The interaction of dendritic cells and T cells in mucosa may support HIV-1 replication, even in subclinical stages of infection.
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In Vivo Distribution of the Human Immunodeficiency Virus/Simian Immunodeficiency Virus Coreceptors: CXCR4, CCR3, and CCR5
TL;DR: T lymphocytes and macrophages in both lymphoid and nonlymphoid tissues are the major cell populations expressing HIV/SIV coreceptors, reaffirming that these cells are themajor targets of HIV/ SIV infection in vivo.
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The Effect of Commencing Combination Antiretroviral Therapy Soon after Human Immunodeficiency Virus Type 1 Infection on Viral Replication and Antiviral Immune Responses
Martin Markowitz,Mika Vesanen,Klara Tenner-Racz,Yunzhen Cao,James M. Binley,Andrew H. Talal,Arlene Hurley,Xia Ji,M. Rashid Chaudhry,Melody Yaman,Sarah S. Frankel,Margo Heath-Chiozzi,John M. Leonard,John P. Moore,Paul Racz,Douglas F. Nixon,David D. Ho +16 more
TL;DR: The persistence of HIV-1 RNA expression in lymphoid tissues and peripheral blood mononuclear cells suggests that elimination of this residual pool of virus should be achieved before considering adjustments in antiretroviral therapeutic regimens.
Journal ArticleDOI
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
John R. Mascola,Gabriela Stiegler,Thomas C. VanCott,Hermann Katinger,Calvin B. Carpenter,Chris E. Hanson,Holly Beary,Deborah Hayes,Sarah S. Frankel,Deborah L. Birx,Mark G. Lewis +10 more
TL;DR: In this paper, the development of the human immunodeficiency virus-1 (HIV-1)/simian immunoviciency virus (SIV) chimeric virus macaque model (SHIV) permits the in vivo evaluation of anti-HIV1 envelope glycoprotein immune responses.