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Debra C. Gigas
Researcher at Harvard University
Publications - 7
Citations - 638
Debra C. Gigas is an academic researcher from Harvard University. The author has contributed to research in topics: Chemotherapy & Temozolomide. The author has an hindex of 5, co-authored 7 publications receiving 619 citations. Previous affiliations of Debra C. Gigas include Brigham and Women's Hospital.
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Journal ArticleDOI
Medical management of patients with brain tumors
TL;DR: There is increasing evidence that brain tumor patients who have not had a seizure do not benefit from prophylactic antiepileptic medications, and low-molecular weight heparin may be more effective than coumadin.
Journal ArticleDOI
Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas.
Lisa Doherty,Debra C. Gigas,Santosh Kesari,Jan Drappatz,Ryan Y. Kim,J. Zimmerman,Louis Ostrowsky,Patrick Y. Wen +7 more
TL;DR: Twenty-eight heavily pretreated patients with recurrent malignant gliomas were administered EGFR inhibitors (gefitinib or erlotinib) in combination with the mTOR (mammalian target of rapamycin) inhibitor sirolimus, and the regimens were reasonably well tolerated.
Journal ArticleDOI
Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults
Santosh Kesari,David Schiff,Lisa Doherty,Debra C. Gigas,Tracy T. Batchelor,Alona Muzikansky,Alison O’Neill,Jan Drappatz,Alice S. Chen-Plotkin,Naren Ramakrishna,Stephanie E. Weiss,Brenda Levy,Joanna Bradshaw,Jean Kracher,Andrea Laforme,Peter McL. Black,Judah Folkman,Mark W. Kieran,Patrick Y. Wen +18 more
TL;DR: Although there were some responders, this four-drug, oral metronomic regimen did not significantly improve OS in this heavily pretreated group of patients who were generally not eligible for conventional protocols.
Journal ArticleDOI
Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults
Santosh Kesari,David Schiff,John W. Henson,Alona Muzikansky,Debra C. Gigas,Lisa Doherty,Tracy T. Batchelor,Janina Longtine,Keith L. Ligon,Susan A. Weaver,Andrea Laforme,Naren Ramakrishna,Peter McL. Black,Jan Drappatz,A. S. Ciampa,Judah Folkman,Mark W. Kieran,Patrick Y. Wen +17 more
TL;DR: Analysis of serial serum samples obtained from 47 patients for four angiogenic peptides failed to show a significant correlation with response or survival for three of the peptides, but higher vascular endothelial growth factor levels showed a trend toward correlation with decreased OS and PFS.
Journal ArticleDOI
Hepatitis B reactivation during glioblastoma treatment with temozolomide: A cautionary note
Milan G. Chheda,J. Drappatz,Norton J. Greenberger,Santosh Kesari,Stephanie E. Weiss,Debra C. Gigas,Lisa Doherty,Patrick Y. Wen +7 more
TL;DR: A 50-year-old right-handed Chinese man with a right temporal glioblastoma in October 2005, after he presented with headaches and progressive left hemiparesis, had a craniotomy with gross total tumor resection and was discharged on rapid dexamethasone taper.