D
Deejay S. Y. Mak
Researcher at Hong Kong University of Science and Technology
Publications - 1
Citations - 236
Deejay S. Y. Mak is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Proinflammatory cytokine & Microglia. The author has an hindex of 1, co-authored 1 publications receiving 179 citations.
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IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline
Amy K.Y. Fu,Kwok Wang Hung,Michael Y. F. Yuen,Xiaopu Zhou,Deejay S. Y. Mak,I.C.W. Chan,Tom H. Cheung,Baorong Zhang,Wing Yu Fu,Foo Y. Liew,Nancy Y. Ip +10 more
TL;DR: IL-33 administration reverses synaptic plasticity impairment and memory deficits in APP/PS1 mice and modulates the innate immune response by polarizing microglia/macrophages toward an antiinflammatory phenotype and reducing the expression of proinflammatory genes, including IL-1β, IL-6, and NLRP3, in the cortices of APP/ PS1 mice.