Deepa Pookot

TL;DR: Findings reveal a new mode by which miRNAs may regulate gene expression, and identify a miRNA that targets promoter sequences and induces gene expression.

TL;DR: A more diverse role for small RNA molecules in the regulation of gene expression than previously recognized is revealed and a potential therapeutic use for dsRNA in targeted gene activation is identified.

TL;DR: The data indicate that miR-449a regulates cell growth and viability in part by repressing the expression of HDAC-1 in prostate cancer cells, providing new insight into the function of miRNA in regulating HDAC expression in normal versus cancerous tissue.

TL;DR: The data provide new insights into the epigenetic mechanism of the action of genistein that may contribute to the chemopreventive activity of this dietary isoflavone and have important implications for epigenetic therapy.

TL;DR: The findings suggest that aberrant AEG-1 expression plays a dominant role as a positive auto-feedback activator of AKT and as a suppressor of FOXO3a in PC cells, and may represent a novel genetic biomarker to serve as an attractive molecular target for new anticancer agents to prevent PC cell progression and metastasis.