Shimane University

About: Shimane University is a education organization based out in Matsue, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 5919 authors who have published 12276 publications receiving 210017 citations. The organization is also known as: Shimane Daigaku.

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

Abstract: Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to induce the invasiveness of these tumors. We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and invasion. Furthermore, IFT20 promotes the efficiency of transport through the Golgi complex. These findings shed new insights into how Ror2 signaling promotes tumor invasiveness, and also advance the understanding of how Golgi structure and transport can be regulated.

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

Abstract: Mutations in mitochondrial DNA (mtDNA) occur at high frequency in human tumors, but whether these mutations alter tumor cell behavior has been unclear. We used cytoplasmic hybrid (cybrid) technology to replace the endogenous mtDNA in a mouse tumor cell line that was poorly metastatic with mtDNA from a cell line that was highly metastatic, and vice versa. Using assays of metastasis in mice, we found that the recipient tumor cells acquired the metastatic potential of the transferred mtDNA. The mtDNA conferring high metastatic potential contained G13997A and 13885insC mutations in the gene encoding NADH (reduced form of nicotinamide adenine dinucleotide) dehydrogenase subunit 6 (ND6). These mutations produced a deficiency in respiratory complex I activity and were associated with overproduction of reactive oxygen species (ROS). Pretreatment of the highly metastatic tumor cells with ROS scavengers suppressed their metastatic potential in mice. These results indicate that mtDNA mutations can contribute to tumor progression by enhancing the metastatic potential of tumor cells.

The status of the tropical rainfall measuring mission (TRMM) after two years in orbit

Abstract: The Tropical Rainfall Measuring Mission (TRMM) satellite was launched on 27 November 1997, and data from all the instruments first became available approximately 30 days after the launch. Since then, much progress has been made in the calibration of the sensors, the improvement of the rainfall algorithms, and applications of these results to areas such as data assimilation and model initialization. The TRMM Microwave Imager (TMI) calibration has been corrected and verified to account for a small source of radiation leaking into the TMI receiver. The precipitation radar calibration has been adjusted upward slightly (by 0.6 dB Z) to match better the ground reference targets; the visible and infrared sensor calibration remains largely unchanged. Two versions of the TRMM rainfall algorithms are discussed. The at-launch (version 4) algorithms showed differences of 40% when averaged over the global Tropics over 30-day periods. The improvements to the rainfall algorithms that were undertaken after launch are presented, and intercomparisons of these products (version 5) show agreement improving to 24% for global tropical monthly averages. The ground-based radar rainfall product generation is discussed. Quality-control issues have delayed the routine production of these products until the summer of 2000, but comparisons of TRMM products with early versions of the ground validation products as well as with rain gauge network data suggest that uncertainties among the TRMM algorithms are of approximately the same magnitude as differences between TRMM products and ground-based rainfall estimates. The TRMM field experiment program is discussed to describe active areas of measurements and plans to use these data for further algorithm improvements. In addition to the many papers in this special issue, results coming from the analysis of TRMM products to study the diurnal cycle, the climatological description of the vertical profile of precipitation, storm types, and the distribution of shallow convection, as well as advances in data assimilation of moisture and model forecast improvements using TRMM data, are discussed in a companion TRMM special issue in the Journal of Climate (1 December 2000, Vol. 13, No. 23).