K
Ken Kawamoto
Researcher at University of California, San Francisco
Publications - 38
Citations - 2877
Ken Kawamoto is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: DNA methylation & Genotype. The author has an hindex of 27, co-authored 38 publications receiving 2800 citations. Previous affiliations of Ken Kawamoto include San Francisco VA Medical Center & University of California.
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Journal ArticleDOI
Identification of novel microRNA targets based on microRNA signatures in bladder cancer.
Takahiro Ichimi,Hideki Enokida,Yasushi Okuno,Ryo Kunimoto,Takeshi Chiyomaru,Ken Kawamoto,Kazuya Kawahara,Kazuki Toki,Kazumori Kawakami,Kenryu Nishiyama,Gozoh Tsujimoto,Masayuki Nakagawa,Naohiko Seki +12 more
TL;DR: The target search algorithm and gene‐expression profiling in BCs revealed that Keratin7 (KRT7) mRNA was a common target of the downregulated miRNAs, and the mRNA expression levels of KRT7 were significantly higher inBCs than in NBEs.
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Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells.
Nobuyuki Kikuno,Hiroaki Shiina,Shinji Urakami,Ken Kawamoto,Hiroshi Hirata,Yuichiro Tanaka,Shahana Majid,Mikio Igawa,Rajvir Dahiya +8 more
TL;DR: The above article, published online on 22 April 2008 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Prof. Peter Lichter, and John Wiley & Sons Ltd.
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Genistein Induces the p21WAF1/CIP1 and p16INK4a Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin Modification
Shahana Majid,Nobuyuki Kikuno,Jason Nelles,Emily J. Noonan,Yuichiro Tanaka,Ken Kawamoto,Hiroshi Hirata,Long C. Li,Hong Zhao,Steve T. Okino,Robert F. Place,Deepa Pookot,Rajvir Dahiya +12 more
TL;DR: The data provide new insights into the epigenetic mechanism of the action of genistein that may contribute to the chemopreventive activity of this dietary isoflavone and have important implications for epigenetic therapy.
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Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity.
Nobuyuki Kikuno,Hiroaki Shiina,Shinji Urakami,Ken Kawamoto,Hiroshi Hirata,Yuichiro Tanaka,Robert F. Place,Deepa Pookot,Shahana Majid,Mikio Igawa,Rajvir Dahiya +10 more
TL;DR: The findings suggest that aberrant AEG-1 expression plays a dominant role as a positive auto-feedback activator of AKT and as a suppressor of FOXO3a in PC cells, and may represent a novel genetic biomarker to serve as an attractive molecular target for new anticancer agents to prevent PC cell progression and metastasis.
Journal ArticleDOI
Combination Analysis of Hypermethylated Wnt-Antagonist Family Genes as a Novel Epigenetic Biomarker Panel for Bladder Cancer Detection
Shinji Urakami,Hiroaki Shiina,Hideki Enokida,Toshifumi Kawakami,Ken Kawamoto,Hiroshi Hirata,Yuichiro Tanaka,Nobuyuki Kikuno,Masayuki Nakagawa,Mikio Igawa,Rajvir Dahiya +10 more
TL;DR: This is the first report demonstrating that M score analysis of Wnt-antagonist genes could serve as an excellent epigenetic biomarker panel for bladder tumors.