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Deepak S. Lala
Researcher at Duke University
Publications - 12
Citations - 2475
Deepak S. Lala is an academic researcher from Duke University. The author has contributed to research in topics: Steroidogenic factor 1 & Nuclear receptor. The author has an hindex of 11, co-authored 12 publications receiving 2414 citations. Previous affiliations of Deepak S. Lala include University of Texas Southwestern Medical Center & Howard Hughes Medical Institute.
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Journal ArticleDOI
Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I.
TL;DR: The model that a steroidogenic cell-selective protein interacts with related promoter elements from three steroidogenic enzymes to regulate their coordinate expression is supported and a cDNA is isolate and characterize that very likely encodes this protein.
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The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis.
Holly A. Ingraham,Deepak S. Lala,Yayoi Ikeda,Xunrong Luo,Wen-Hui Shen,Mark W. Nachtigal,Rula Abbud,John H. Nilson,Keith L. Parker +8 more
TL;DR: Novel roles are established in reproductive function of Steroidogenic factor 1 at other levels of the hypothalamic/pituitary/gonadal axis and a possible mechanism for the impaired gonadotropin expression in Ftz-F1-disrupted mice is established.
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Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression
TL;DR: It is shown thatSF-1 is selectively expressed in steroidogenic cells, that an antiserum against its protein product specifically abolishes the SF-1-related gel-shift complex, and that its coexpression increases promoter activity of the 21-hydroxylase 5'-flanking region in transfection experiments.
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Steroidogenic factor 1: an essential mediator of endocrine development.
Keith L. Parker,Douglas A. Rice,Deepak S. Lala,Yayoi Ikeda,Xunrong Luo,Margaret Wong,Marit Bakke,Liping Zhao,Claudia Frigeri,Neil A. Hanley,Nancy R. Stallings,Bernard P. Schimmer +11 more
TL;DR: This chapter will review the experiments that established SF-1 as a pivotal, global determinant of endocrine differentiation and function, as well as the current status of research aimed at delineating its roles in specific tissues.
Journal ArticleDOI
Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols
Deepak S. Lala,Peter Syka,Steven B. Lazarchik,David J. Mangelsdorf,Keith L. Parker,Richard A. Heyman +5 more
TL;DR: It is shown that 25, 26, or 27-hydroxycholesterol, known suppressors of cholesterol biosynthesis, enhance SF-1-dependent transcriptional activity and this results suggest that specific oxysterols may mediate transcriptional activation via different intracellular receptors.