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Neil A. Hanley
Researcher at University of Manchester
Publications - 146
Citations - 8909
Neil A. Hanley is an academic researcher from University of Manchester. The author has contributed to research in topics: Cellular differentiation & Stem cell. The author has an hindex of 48, co-authored 129 publications receiving 7823 citations. Previous affiliations of Neil A. Hanley include Manchester Academic Health Science Centre & University of Southampton.
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Journal ArticleDOI
Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes
Ignasi Moran,Ildem Akerman,Martijn van de Bunt,Martijn van de Bunt,Ruiyu Xie,Marion Benazra,Takao Nammo,Luis Arnes,Nikolina Nakic,Javier García-Hurtado,Santiago A. Rodríguez-Seguí,Lorenzo Pasquali,Claire Sauty-Colace,Anthony Beucher,Raphael Scharfmann,Joris van Arensbergen,Paul Johnson,Paul Johnson,Andrew Berry,Clarence Lee,Timothy T. Harkins,Valery Gmyr,François Pattou,Julie Kerr-Conte,Lorenzo Piemonti,Thierry Berney,Neil A. Hanley,Anna L. Gloyn,Lori Sussel,Linda Langman,Kenneth L. Brayman,Maike Sander,Mark I. McCarthy,Mark I. McCarthy,Philippe Ravassard,Jorge Ferrer,Jorge Ferrer +36 more
TL;DR: A comprehensive strand-specific transcriptome map of human pancreatic islets and β cells is reported, and a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology are revealed.
Journal ArticleDOI
Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions.
Catherine E Forristal,Kate L Wright,Neil A. Hanley,Richard O.C. Oreffo,Franchesca D. Houghton +4 more
TL;DR: It is demonstrated that a low oxygen tension is preferential for the maintenance of a highly proliferative, pluripotent population of hES cells.
Journal ArticleDOI
Steroidogenic factor 1: an essential mediator of endocrine development.
Keith L. Parker,Douglas A. Rice,Deepak S. Lala,Yayoi Ikeda,Xunrong Luo,Margaret Wong,Marit Bakke,Liping Zhao,Claudia Frigeri,Neil A. Hanley,Nancy R. Stallings,Bernard P. Schimmer +11 more
TL;DR: This chapter will review the experiments that established SF-1 as a pivotal, global determinant of endocrine differentiation and function, as well as the current status of research aimed at delineating its roles in specific tissues.
Journal ArticleDOI
Beta cell differentiation during early human pancreas development
K Piper,S Brickwood,Lee Turnpenny,Iain T. Cameron,Stephen G. Ball,David I. Wilson,Neil A. Hanley +6 more
TL;DR: From the inception of pancreatic formation, embryonic pancreatic epithelial cells expressed nuclear PDX1 and cytoplasmic CK19, which support the function of fetal beta cells as true endocrine cells by the end of the first trimester of human pregnancy.
Journal ArticleDOI
Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alström syndrome.
Tom Hearn,Glenn L. Renforth,Cosma Spalluto,Neil A. Hanley,K Piper,S Brickwood,Chris White,Vincent Connolly,J F Taylor,Isabelle Russell-Eggitt,Dominique Bonneau,Mark Walker,David I. Wilson +12 more
TL;DR: Alström syndrome is believed to be the first human disease gene characterized by autosomal recessive inheritance to be identified as a result of a balanced reciprocal translocation and six different mutations were detected in seven families, confirming that ALMS1 is the gene underlying Alstr Öm syndrome.