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Deepu Alex
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 34
Citations - 821
Deepu Alex is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 27 publications receiving 534 citations. Previous affiliations of Deepu Alex include MedStar Georgetown University Hospital & University of British Columbia.
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Journal ArticleDOI
SMARCA4-Deficient Thoracic Sarcomatoid Tumors Represent Primarily Smoking-Related Undifferentiated Carcinomas Rather Than Primary Thoracic Sarcomas.
Natasha Rekhtman,Joseph Montecalvo,Jason C. Chang,Deepu Alex,Ryan Ptashkin,Ni Ai,Jennifer L. Sauter,Brie Kezlarian,Achim A. Jungbluth,Patrice Desmeules,Amanda Beras,Justin A. Bishop,Andrew J. Plodkowski,Mrinal M. Gounder,Adam J. Schoenfeld,Azadeh Namakydoust,Bob T. Li,Charles M. Rudin,Gregory J. Riely,David R. Jones,Marc Ladanyi,William D. Travis +21 more
TL;DR: SD-TSTs represent primarily smoking-associated undifferentiated/de-differentiated carcinomas rather than primary thoracic sarcomas, and have unique clinicopathologic characteristics, supporting their recognition as a distinct entity.
Journal ArticleDOI
Goa1p of Candida albicans localizes to the mitochondria during stress and is required for mitochondrial function and virulence.
Adrienne V. Bambach,Mariana P. Fernandes,Anup K. Ghosh,Michael Kruppa,Deepu Alex,Dongmei Li,William A. Fonzi,Neeraj Chauhan,Nuo Sun,Orlando A. Agrellos,Orlando A. Agrellos,Anibal E. Vercesi,Ronda J. Rolfes,Richard Calderone +13 more
TL;DR: It is shown that GOA31, but not the wt or GOA32, had decreased respiration and mitochondrial membrane potential such that mutant cells are unable to drive oxidative phosphorylation, the first report in C. albicans of a respiratory defect caused by a loss of mitochondrial membranes potential.
Journal ArticleDOI
Antifungal drug discovery: the process and outcomes
Richard Calderone,Nuo Sun,Francoise Gay-Andrieu,William C. Groutas,Pathum M. Weerawarna,Sridhar Prasad,Deepu Alex,Dongmei Li +7 more
TL;DR: The dogma on antifungal discovery is examined and it is suggested that a major thrust in technologies such as structural biology, homology modeling and virtual imaging is needed to drive discovery.
Journal ArticleDOI
Enzymatic Dysfunction of Mitochondrial Complex I of the Candida albicans goa1 Mutant Is Associated with Increased Reactive Oxidants and Cell Death
Dongmei Li,Hui Chen,Abigail Florentino,Deepu Alex,Patricia Sikorski,William A. Fonzi,Richard Calderone +6 more
TL;DR: GOA1 is required for a functional CI and partially for the AOX pathway; loss of GOA1 compromises cell survival; the observation of increased ROS production associated with a defective CI and PCD is reminiscent of mitochondrial studies of patients with some types of neurodegenerative diseases where CI and/or CIII dysfunctions lead to increased ROS and apoptosis.
Journal ArticleDOI
Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations.
Yoshiyuki Suehara,Deepu Alex,Anita S. Bowman,Sumit Middha,Ahmet Zehir,Debyani Chakravarty,Lu Wang,George Jour,Khedoudja Nafa,Takuo Hayashi,Achim A. Jungbluth,Denise Frosina,Emily K. Slotkin,Neerav Shukla,Paul A. Meyers,John H. Healey,Meera Hameed,Marc Ladanyi +17 more
TL;DR: A new genomically based algorithm for directing patients with osteosarcoma to clinical trial options is proposed, and at least 40% of patients have tumors harboring PDGFRA or VEGFA amplification, representing candidate subsets for clinical evaluation of additional therapeutic options.