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Pathum M. Weerawarna
Researcher at Northwestern University
Publications - 17
Citations - 414
Pathum M. Weerawarna is an academic researcher from Northwestern University. The author has contributed to research in topics: Protease & Norovirus. The author has an hindex of 9, co-authored 16 publications receiving 327 citations. Previous affiliations of Pathum M. Weerawarna include Wichita State University & University of Colombo.
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Journal ArticleDOI
Antifungal drug discovery: the process and outcomes
Richard Calderone,Nuo Sun,Francoise Gay-Andrieu,William C. Groutas,Pathum M. Weerawarna,Sridhar Prasad,Deepu Alex,Dongmei Li +7 more
TL;DR: The dogma on antifungal discovery is examined and it is suggested that a major thrust in technologies such as structural biology, homology modeling and virtual imaging is needed to drive discovery.
Journal ArticleDOI
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles.
Sivakoteswara Rao Mandadapu,Pathum M. Weerawarna,Mallikarjuna Reddy Gunnam,Kevin R. Alliston,Gerald H. Lushington,Yunjeong Kim,Kyeong-Ok Chang,William C. Groutas +7 more
TL;DR: The synthesized compounds were found to inhibit norovirus 3CL protease in vitro and to also exhibit potent anti-norovirus activity in a cell-based replicon system.
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Structure-Guided Design and Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease. Structure-Activity Relationships and Biochemical, X-ray Crystallographic, Cell-Based, and In Vivo Studies.
Anushka C. Galasiti Kankanamalage,Yunjeong Kim,Pathum M. Weerawarna,Roxanne Adeline Z. Uy,Vishnu C. Damalanka,Sivakoteswara Rao Mandadapu,Kevin R. Alliston,N. Mehzabeen,Kevin P. Battaile,Scott Lovell,Kyeong-Ok Chang,William C. Groutas +11 more
TL;DR: The optimization of dipeptidyl inhibitors of norovirus 3C-like protease is described using iterative SAR, X-ray crystallographic, and enzyme and cell-based studies and in vivo efficacy of an inhibitor is demonstrated using the murine model of Norovirus infection.
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Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction
Jose I. Juncosa,Takaya Kenji,Hoang V. Le,Matthew J. Moschitto,Pathum M. Weerawarna,Romila Mascarenhas,Dali Liu,Stephen L. Dewey,Richard B. Silverman +8 more
TL;DR: In vivo studies in freely moving rats showed that 5 was dramatically superior to CPP-115 in suppressing the release of dopamine in the corpus striatum, which occurs subsequent to either an acute cocaine or nicotine challenge.
Journal ArticleDOI
Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus
Sivakoteswara Rao Mandadapu,Pathum M. Weerawarna,Allan M. Prior,Roxanne Adeline Z. Uy,Sridhar Aravapalli,Kevin R. Alliston,Gerald H. Lushington,Yunjeong Kim,Duy H. Hua,Kyeong-Ok Chang,William C. Groutas +10 more
TL;DR: The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported.