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Dehong Yu
Researcher at Shanghai Jiao Tong University
Publications - 29
Citations - 608
Dehong Yu is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Ototoxicity & Angiogenesis. The author has an hindex of 12, co-authored 26 publications receiving 492 citations.
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Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature.
TL;DR: A drug delivery system (DDS), nanoparticles conjugated with K237-(HTMYYHHYQHHL) peptides for tumor neovasculature targeting drug delivery, which offers a new strategy for paclitaxel chemotherapy application and it could also be used to carry other chemotherapeutic drugs, genes, and proteins with antiangiogenic activity for antiangsiogenic cancer therapy.
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Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells.
TL;DR: The specific apoptotic mechanism of DCA as distinguished from the cisplatin may be partly responsible for the synergy and further in vivo study on combination chemotherapy of the two agents in cervical cancer xenografts in mice is warranted.
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Nanoparticle-mediated drug delivery to tumor neovasculature to combat P-gp expressing multidrug resistant cancer.
Fan Bai,Chao Wang,Qin Lu,Mei Zhao,Fu-Qiang Ban,Dehong Yu,Ying-Yun Guan,Xin Luan,Ya-Rong Liu,Hong-Zhuan Chen,Chao Fang,Chao Fang +11 more
TL;DR: The results suggest that the nanoparticles targeting drug to tumor neovasculature may be a promising strategy for the treatment of multidrug resistant cancer.
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Current Strategies to Combat Cisplatin-Induced Ototoxicity.
TL;DR: The focus of this review is to identify candidate agents as novel molecular targets, drug administration routes, delivery systems, and dosage schedules, and animal models of cisplatin ototoxicity that have been used to evaluate drug efficacy and side effect prevention.
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Suppression of colorectal cancer subcutaneous xenograft and experimental lung metastasis using nanoparticle-mediated drug delivery to tumor neovasculature.
Chao Wang,Mei Zhao,Ya-Rong Liu,Xin Luan,Ying-Yun Guan,Qin Lu,Dehong Yu,Fan Bai,Hong-Zhuan Chen,Chao Fang +9 more
TL;DR: F56-VCR-NP significantly prolonged the mouse survival with no obvious toxicity in the CT-26 lung metastasis mice model, and this pronounced antitumor effect was closely related with the decreased microvessel density in the metastases.