H
Hong-Zhuan Chen
Researcher at Shanghai University
Publications - 234
Citations - 8149
Hong-Zhuan Chen is an academic researcher from Shanghai University. The author has contributed to research in topics: Drug delivery & Cancer. The author has an hindex of 41, co-authored 222 publications receiving 6127 citations. Previous affiliations of Hong-Zhuan Chen include Chinese Academy of Sciences & Shanghai Jiao Tong University.
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Journal ArticleDOI
Aptamer-functionalized PEG–PLGA nanoparticles for enhanced anti-glioma drug delivery
Jianwei Guo,Xiaoling Gao,Lina Su,Lina Su,Huimin Xia,Guangzhi Gu,Zhiqing Pang,Xinguo Jiang,Lei Yao,Jun Chen,Hong-Zhuan Chen +10 more
TL;DR: The potential utility of AS1411-functionalized nanoparticles for a therapeutic application in the treatment of gliomas was demonstrated and significantly enhanced cellular association of nanoparticles in C6 glioma cells, and increased the cytotoxicity of its payload.
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Nanoparticles Coated with Neutrophil Membranes Can Effectively Treat Cancer Metastasis.
Ting Kang,Qianqian Zhu,Dan Wei,Jingxian Feng,Jianhui Yao,Tianze Jiang,Qingxiang Song,Xunbin Wei,Hong-Zhuan Chen,Xiaoling Gao,Jun Chen +10 more
TL;DR: A nanosize neutrophil-mimicking drug delivery system (NM-NP) that can neutralize CTCs in the circulation and inhibit the formation of a metastatic niche is developed.
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Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration
Xiaoling Gao,Bingxian Wu,Qizhi Zhang,Jun Chen,Jianhua Zhu,Weiwei Zhang,Zhengxin Rong,Hong-Zhuan Chen,Xinguo Jiang +8 more
TL;DR: Results clearly indicated wheat germ agglutinin-modified nanoparticles might serve as promising carriers especially for biotech drugs such as peptides and proteins.
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Lipoprotein-Based Nanoparticles Rescue the Memory Loss of Mice with Alzheimer’s Disease by Accelerating the Clearance of Amyloid-Beta
Qingxiang Song,Meng Huang,Lei Yao,Xiaolin Wang,Xiao Gu,Juan Chen,Jun Chen,Jialin Huang,Quanyin Hu,Ting Kang,Zhengxing Rong,Hong Qi,Gang Zheng,Hong-Zhuan Chen,Xiaoling Gao +14 more
TL;DR: The findings here provided the direct evidence of a biomimetic nanostructure crossing the blood-brain barrier, capturing Aβ and facilitating its degradation by glial cells, indicating that ApoE3-rHDL might serve as a novel nanomedicine for disease modification in AD by accelerating Aβ clearance.
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Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature.
TL;DR: A drug delivery system (DDS), nanoparticles conjugated with K237-(HTMYYHHYQHHL) peptides for tumor neovasculature targeting drug delivery, which offers a new strategy for paclitaxel chemotherapy application and it could also be used to carry other chemotherapeutic drugs, genes, and proteins with antiangiogenic activity for antiangsiogenic cancer therapy.